ArticleJournal of cell science2005
Golgi polarization in a strong electric field.
Article in Journal of cell science, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Making Sense of Electrical Stimulation: A Meta-analysis for Wound Healing.Annals of biomedical engineering · 2024Pooled it
- Electrical aspects of skin as a pathway to engineering skin devices.APL bioengineering · 2021Review
- Electrotaxis-on-Chip to Quantify Neutrophil Migration Towards Electrochemical Gradients.Frontiers in immunology · 2021Article
- Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology.Journal of cellular and molecular medicine · 2018Article
- Electric field-induced migration and intercellular stress alignment in a collective epithelial monolayer.Molecular biology of the cell · 2018Article
- Reversing the direction of galvanotaxis with controlled increases in boundary layer viscosity.Physical biology · 2018Article
- Homogeneity evaluation of mesenchymal stem cells based on electrotaxis analysis.Scientific reports · 2017Article
- A current affair: electrotherapy in wound healing.Journal of multidisciplinary healthcare · 2017Review
- Influence of Electric Fields and Conductivity on Pollen Tube Growth assessed via Electrical Lab-on-Chip.Scientific reports · 2016Article
- Electrotaxis Studies of Lung Cancer Cells using a Multichannel Dual-electric-field Microfluidic Chip.Journal of visualized experiments : JoVE · 2015Article
- KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis.Nature communications · 2015Article
- Exploration of molecular pathways mediating electric field-directed Schwann cell migration by RNA-seq.Journal of cellular physiology · 2015Article
- Collective migration exhibits greater sensitivity but slower dynamics of alignment to applied electric fields.Cellular and molecular bioengineering · 2015Article
- A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum.Science signaling · 2015Article
- ARP2/3 complex is required for directional migration of neural stem cell-derived oligodendrocyte precursors in electric fields.Stem cell research & therapy · 2015Article
- Physiological electrical signals promote chain migration of neuroblasts by up-regulating P2Y1 purinergic receptors and enhancing cell adhesion.Stem cell reviews and reports · 2015Article
- Polarizing intestinal epithelial cells electrically through Ror2.Journal of cell science · 2014Article
- The Electrical Response to Injury: Molecular Mechanisms and Wound Healing.Advances in wound care · 2014Review
- Harnessing the Electric Spark of Life to Cure Skin Wounds.Advances in wound care · 2014Review
- Endogenous electric currents might guide rostral migration of neuroblasts.EMBO reports · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Directional cell migration requires proper cell polarization. The redistribution of the Golgi apparatus is an important event in the polarization and migration of many types of cells, as a polarized Golgi supplies membrane components for leading edge protrusion. Direct current electric fields induce directional cell migration in a wide variety of cells. Here we show that electric fields of 300 mV/mm induce robust Golgi polarization and directional cell migration in CHO cells. Asymmetric Src and PI 3-kinase signalling as well as actin polymerization are essential for electric field-induced Golgi polarization and directional cell migration. The Golgi polarizes at the same time as cells change morphology and migrate directionally in response to an electric field. Golgi polarization in turn significantly reinforces and maintains optimal electrotaxis. It is not known whether electrical signals, when contradicting other directional cues, are still able to polarize cells and direct cell migration. Most strikingly, Golgi polarization and cell migration simply follow the direction of an applied electric field and ignore all other cues generated by wounding a monolayer of CHO cells. Thus, an electric field of 300 mV/mm is the predominant cue to polarize the Golgi and direct cell migration mediated by PI 3-kinase and Src signalling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.