ArticleThe Journal of experimental medicine2005
An orderly inactivation of intracellular retention signals controls surface expression of the T cell antigen receptor.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- T cell receptors equipped with ICOS provide T cells with durable anti-tumor response.Molecular cancer · 2026Article
- Discordant Restoration of TCR Expression and Function by CD247 Somatic Reversions.Journal of clinical immunology · 2025Article
- The TCR and LCK: foundations for T-cell activation and therapeutic innovation.Frontiers in immunology · 2025Review
- Harnessing CD3 diversity to optimize CAR T cells.Nature immunology · 2023Article
- Modulating T Cell Responses by Targeting CD3.Cancers · 2023Review
- The role of the different CD3γ domains in TCR expression and signaling.Frontiers in immunology · 2022Article
- Article
- Porcine CD3(+)NKp46(+) Lymphocytes Have NK-Cell Characteristics and Are Present in Increased Frequencies in the Lungs of Influenza-Infected Animals.Frontiers in immunology · 2016Article
- Dimerization-dependent folding underlies assembly control of the clonotypic αβT cell receptor chains.The Journal of biological chemistry · 2015Article
- A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.Immunity · 2015Article
- Quantitative analysis of T cell receptor complex interaction sites using genetically encoded photo-cross-linkers.ACS chemical biology · 2014Article
- Structure of the chicken CD3εδ/γ heterodimer and its assembly with the αβT cell receptor.The Journal of biological chemistry · 2014Article
- Article
- Evidence for a functional sidedness to the alphabetaTCR.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Essential function for the GTPase TC21 in homeostatic antigen receptor signaling.Nature immunology · 2009Article
- N-terminal mutants of herpes simplex virus type 2 gH are transported without gL but require gL for function.Journal of virology · 2007Article
- Role of the stable signal peptide and cytoplasmic domain of G2 in regulating intracellular transport of the Junín virus envelope glycoprotein complex.Journal of virology · 2006Article
- Normal T-cell development and immune functions in TRIM-deficient mice.Molecular and cellular biology · 2006Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exit from the endoplasmic reticulum (ER) is an important checkpoint for proper assembly of multimeric plasma membrane receptors. The six subunits of the T cell receptor (TCR; TCRalpha, TCRbeta, CD3gamma, CD3delta, CD3epsilon, and CD3zeta) are each endowed with ER retention/retrieval signals, and regulation of its targeting to the plasma membrane is therefore especially intriguing. We have studied the importance of the distinct ER retention signals at different stages of TCR intracellular assembly. To this end, we have characterized first the presence of ER retention signals in CD3gamma. Despite the presence of multiple ER retention signals in CD3gamma, epsilongamma dimers reach the cell surface when the single CD3epsilon ER retention signal is deleted. Furthermore, inclusion of this CD3epsilon mutant promoted plasma membrane expression of incomplete alphabetagammaepsilon and alphabetadeltaepsilon complexes without CD3zeta. It therefore appears that the CD3epsilon ER retention signal is dominant and that it is only overridden upon the incorporation of CD3zeta. We propose that the stepwise assembly of the TCR complex guarantees that all assembly intermediates have at least one functional ER retention signal and that only a full signaling-competent TCR complex is expressed on the cell surface.
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