ArticleThe Journal of experimental medicine2005
T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 125 citations in OpenAlex.
- Mechanotransduction through T cell receptors: consensus, controversies and future outlooks.Experimental & molecular medicine · 2026Review
- The resting and ligand-bound states of the membrane-embedded human T-cell receptor-CD3 complex.Nature communications · 2025Article
- A Story of Kinases and Adaptors: The Role of Lck, ZAP-70 and LAT in Switch Panel Governing T-Cell Development and Activation.Biology · 2023Review
- Decoding the crosstalk between mevalonate metabolism and T cell function.Immunological reviews · 2023Review
- A reengineered common chain cytokine augments CD8+ T cell-dependent immunotherapy.JCI insight · 2022Article
- Public and private human T-cell clones respond differentially to HCMV antigen when boosted by CD3 copotentiation.Blood advances · 2020Article
- Direct Regulation of the T Cell Antigen Receptor's Activity by Cholesterol.Frontiers in cell and developmental biology · 2020Review
- miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling.Cell death & disease · 2019Article
- Peptide-MHC (pMHC) binding to a human antiviral T cell receptor induces long-range allosteric communication between pMHC- and CD3-binding sites.The Journal of biological chemistry · 2018Article
- High-Affinity Ligands Can Trigger T Cell Receptor Signaling Without CD45 Segregation.Frontiers in immunology · 2018Article
- Dimensions and Interactions of Large T-Cell Surface Proteins.Frontiers in immunology · 2018Review
- An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role.Nature communications · 2017Article
- Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse.Frontiers in immunology · 2016Review
- Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo.Science advances · 2015Article
- Quantitative Analysis of the Association Angle between T-cell Receptor Vα/Vβ Domains Reveals Important Features for Epitope Recognition.PLoS computational biology · 2015Article
- Membrane-mediated regulation of the intrinsically disordered CD3ϵ cytoplasmic tail of the TCR.Biophysical journal · 2015Article
- Detection of constant domain of human T cell antigen receptor alpha-chain via novel monoclonal antibody 7F18.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2014Article
- Membrane association of the CD3ε signaling domain is required for optimal T cell development and function.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- IgG Fab fragments forming bivalent complexes by a conformational mechanism that is reversible by osmolytes.The Journal of biological chemistry · 2012Article
- T cell antigen recognition at the cell membrane.Molecular immunology · 2012Review
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The T cell receptor (TCR) can recognize a variety of cognate peptide/major histocompatibility complex (pMHC) ligands and translate their affinity into distinct cellular responses. To achieve this, the nonsignaling alphabeta heterodimer communicates ligand recognition to the CD3 signaling subunits by an unknown mechanism. In thymocytes, we found that both positive- and negative-selecting pMHC ligands expose a cryptic epitope in the CD3 complex upon TCR engagement. This conformational change is induced in vivo and requires the expression of cognate MHC. We conclude that TCR engagement with a cognate pMHC ligand induces a conformational change in the CD3 complex of thymocytes and propose that this marks an initial event during thymic selection that signals the recognition of self-antigen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.