ArticleThe Journal of experimental medicine2005
Twisting tails exposed: the evidence for TCR conformational change.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Membrane-mediated regulation of the intrinsically disordered CD3ϵ cytoplasmic tail of the TCR.Biophysical journal · 2015Article
- Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45.Cold Spring Harbor symposia on quantitative biology · 2013Article
- T cell antigen recognition at the cell membrane.Molecular immunology · 2012Review
- An alternative conformation of the T-cell receptor alpha constant region.Journal of molecular biology · 2010Article
- The SCHOOL of nature: I. Transmembrane signaling.Self/nonself · 2010Article
- T cell receptor triggering by force.Trends in immunology · 2010Article
- The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- The receptor deformation model of TCR triggering.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- A role for "self" in T-cell activation.Seminars in immunology · 2007Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism by which the ligand occupancy state of the T cell receptor complex is converted into intracellular signaling information has been a controversial topic. Although the majority of structural studies argue against a conformational change, recent studies support the possibility for such a change within the CD3 components of the TCR complex. In this commentary, the evidence for TCR conformational change is reviewed and potential mechanisms for its initiation are explored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.