Evidence map›Paper›PMID 15727682›Full record

Trial reportNutrition journal2005

One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women.

Bahram H Arjmandi, Edralin A Lucas, Dania A Khalil, Latha Devareddy, Brenda J Smith, Jennifer McDonald, Andrea B Arquitt, Mark E Payton, Claudia Mason

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00668447 (Soy Proteins and Isoflavones Impact Bone Mineral Density in Older Women), which is not on this map. Cited by 47 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 11 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00668447 phase4completednot on this map

Soy Proteins and Isoflavones Impact Bone Mineral Density in Older Women

TypeinterventionalSponsorUnited States Department of Agriculture (USDA)Ran2001 to 2005Enrolled97ConditionsOsteoporosisArmsSoy Isolate, Control protein, Novasoy isoflavones, Placebo tablets
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 11 syntheses or guidelines pooled it, 150 citations in OpenAlex.

  1. Pooled it
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  3. Isoflavone intervention and its impact on bone mineral density in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Pooled it
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  13. Bone mineral density in postmenopausal Chinese women treated with calcium fortification in soymilk and cow's milk.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012
    Trial
  14. The effect of soy isoflavone on bone mineral density in postmenopausal Taiwanese women with bone loss: a 2-year randomized double-blind placebo-controlled study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Bahram H ArjmandiDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA. arjmand@okstate.edu
Edralin A Lucas
Dania A Khalil
Latha Devareddy
Brenda J Smith
Jennifer McDonald
Andrea B Arquitt
Mark E Payton
Claudia Mason
Oklahoma State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough soy protein and its isoflavones have been reported to reduce the risk of osteoporosis in peri- and post-menopausal women, most of these studies are of short duration (i.e. six months). The objective of this study was to examine if one year consumption of soy-containing foods (providing 25 g protein and 60 mg isoflavones) exerts beneficial effects on bone in postmenopausal women.

methodsEighty-seven eligible postmenopausal women were randomly assigned to consume soy or control foods daily for one year. Bone mineral density (BMD) and bone mineral content (BMC) of the whole body, lumbar (L1-L4), and total hip were measured using dual energy x-ray absorptiometry at baseline and after one year. Blood and urine markers of bone metabolism were also assessed. RESULTS AND DISCUSSION: Sixty-two subjects completed the one-year long study. Whole body and lumbar BMD and BMC were significantly decreased in both the soy and control groups. However, there were no significant changes in total hip BMD and BMC irrespective of treatment. Both treatments positively affected markers of bone formation as indicated by increased serum bone-specific alkaline phosphatase (BSAP) activity, insulin-like growth factor-I (IGF-I), and osteocalcin (BSAP: 27.8 and 25.8%, IGF-I: 12.8 and 26.3%, osteocalcin: 95.2 and 103.4% for control and soy groups, respectively). Neither of the protein supplements had any effect on urinary deoxypyridinoline excretion, a marker of bone resorption.

conclusionOur findings suggest that although one year supplementation of 25 g protein per se positively modulated markers of bone formation, this amount of protein was unable to prevent lumbar and whole body bone loss in postmenopausal women.

Indexed as

DietPostmenopauseAbsorptiometry, PhotonAlkaline PhosphataseAmino AcidsBiomarkersBody Mass IndexBone DensityCalciumDietary CarbohydratesDietary ProteinsDiet RecordsDouble-Blind MethodEnergy IntakeFemaleHumansAlkaline PhosphataseAmino AcidsBiomarkersCalciumdeoxypyridinolineDietary CarbohydratesDietary ProteinsInsulin-Like Growth Factor IOsteocalcinSoybean Proteins

Identifiers

PMID15727682
PMCPMC554088
OpenAlexW1960124154

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.