ArticleBehavioral neuroscience2005
Purkinje cell loss by OX7-saporin impairs excitatory and inhibitory eyeblink conditioning.
Article in Behavioral neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Brain areas interconnected to ventral pathway circuits are independently able to induce enhancement in object recognition memory and cause reversal in object recognition memory deficit.CNS neuroscience & therapeutics · 2024Article
- Localization of the cerebellar cortical zone mediating acquisition of eyeblink conditioning in rats.Neurobiology of learning and memory · 2014Article
- Conditioned inhibition in a rodent model of attention-deficit/hyperactivity disorder.Behavioral neuroscience · 2011Article
- Neural circuitry and plasticity mechanisms underlying delay eyeblink conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Review
- MK-801 administration during neonatal ethanol withdrawal attenuates interpositus cell loss and juvenile eyeblink conditioning deficits.Alcohol (Fayetteville, N.Y.) · 2010Article
- Stimulation of the lateral geniculate, superior colliculus, or visual cortex is sufficient for eyeblink conditioning in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2009Article
- Changes in inhibition during differential eyeblink conditioning with increased training.Learning & behavior · 2008Article
- Perirhinal cortex lesions impair feature-negative discrimination.Neurobiology of learning and memory · 2006Article
- Perirhinal cortex lesions impair simultaneous but not serial feature-positive discrimination learning.Behavioral neuroscience · 2006Article
- Differential effects of cerebellar inactivation on eyeblink conditioned excitation and inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Purkinje cell loss by OX7-saporin impairs acquisition and extinction of eyeblink conditioning.Learning & memory (Cold Spring Harbor, N.Y.)Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cerebellar cortical contributions to eyeblink conditioned excitation have been examined extensively. In contrast, very little evidence exists concerning the role of the cerebellar cortex in eyeblink conditioned inhibition. In the current study, rats were given intraventricular infusions of the immunotoxin OX7-saporin to selectively destroy Purkinje cells throughout the cerebellar cortex following excitatory conditioning. After a 2-week postinfusion period, the rats were given reacquisition training. After reacquiring excitatory conditioning, the rats were trained in a feature-negative discrimination procedure to establish conditioned inhibition. Rats treated with OX7-saporin showed impaired reacquisition of excitatory conditioning and acquisition of conditioned inhibition. The results suggest that Purkinje cells play important, but different, roles in conditioned excitation and inhibition in rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.