ReviewHuman genetics2005
Genes and human elite athletic performance.
Review in Human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Prediction of success in sports based on assumed individual genetic predisposition: lack of association with the C > T variant in the ACTN3 gene.Journal of physiological anthropology · 2025Pooled it
- Effects of Genetic Variation on Endurance Performance, Muscle Strength, and Injury Susceptibility in Sports: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Association of the ACTN3 R577X (rs1815739) polymorphism with elite power sports: A meta-analysis.PloS one · 2019Pooled it
- The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis.PloS one · 2013Pooled it
- The ACTN3 genotype in soccer players in response to acute eccentric training.European journal of applied physiology · 2012Trial
- Importance of selected genetic determinants on endurance performance and physical strength: a narrative review.Frontiers in physiology · 2025Review
- Alterations in FoxO3a, NF-κB, and MuRF1 Expression in the Soleus Muscle of Male Rats Following High-Intensity Interval Training and Detraining.Doklady. Biochemistry and biophysics · 2024Article
- Association between ComplexGenes · 2024Article
- Article
- Relationship between Athletes' Big Five Model of Personality and Athletic Performance: Meta-Analysis.Behavioral sciences (Basel, Switzerland) · 2024Review
- The Relationship between Changes inJournal of cardiovascular development and disease · 2023Review
- The non-modifiable factors age, gender, and genetics influence resistance exercise.Frontiers in aging · 2022Review
- Genetic characteristics of competitive swimmers: a review.Biology of sport · 2022Review
- Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study.Journal of biomedical science · 2021Article
- An Identical Twin Study on Human Achilles Tendon Adaptation: Regular Recreational Exercise at Comparatively Low Intensities Can Increase Tendon Stiffness.Frontiers in physiology · 2021Article
- Prediction and Identification of Power Performance Using Polygenic Models of Three Single-Nucleotide Polymorphisms in Chinese Elite Athletes.Frontiers in genetics · 2021Article
- Genetic test for the personalization of sport training.Acta bio-medica : Atenei Parmensis · 2020Review
- Sport and exercise genomics: the FIMS 2019 consensus statement update.British journal of sports medicine · 2020Article
- Genetics and the Elite Athlete: Our Understanding in 2020.Indian journal of orthopaedics · 2020Article
- Scaling Invariance of Sports Sex Gap.Frontiers in physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical fitness is a complex phenotype influenced by a myriad of environmental and genetic factors, and variation in human physical performance and athletic ability has long been recognised as having a strong heritable component. Recently, the development of technology for rapid DNA sequencing and genotyping has allowed the identification of some of the individual genetic variations that contribute to athletic performance. This review will examine the evidence that has accumulated over the last three decades for a strong genetic influence on human physical performance, with an emphasis on two sets of physical traits, viz. cardiorespiratory and skeletal muscle function, which are particularly important for performance in a variety of sports. We will then review recent studies that have identified individual genetic variants associated with variation in these traits and the polymorphisms that have been directly associated with elite athlete status. Finally, we explore the scientific implications of our rapidly growing understanding of the genetic basis of variation in performance.
Indexed as
Identifiers
15726413What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.