ArticleImmunogenetics2005
Patterns of variability at the major histocompatibility class II alpha locus in Atlantic salmon contrast with those at the class I locus.
Article in Immunogenetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Farmed Escapees Threaten MHC Diversity in Wild Atlantic Salmon.Evolutionary applications · 2026Article
- Fate of MHCII in salmonids following 4WGD.Immunogenetics · 2021Article
- Temporal and spatial instability in neutral and adaptive (MHC) genetic variation in marginal salmon populations.Scientific reports · 2017Article
- Egernia stokesii (gidgee skink) MHC I positively selected sites lack concordance with HLA peptide binding regions.Immunogenetics · 2017Article
- Combining molecular evolution and environmental genomics to unravel adaptive processes of MHC class IIB diversity in European minnows (Phoxinus phoxinus).Ecology and evolution · 2013Article
- Selection and phylogenetics of salmonid MHC class I: wild brown trout (Salmo trutta) differ from a non-native introduced strain.PloS one · 2013Article
- Positive selection pressure within teleost Toll-like receptors tlr21 and tlr22 subfamilies and their response to temperature stress and microbial components in zebrafish.Molecular biology reports · 2012Article
- Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water.Evolutionary applications · 2011Article
- Contrasting responses to selection in class I and class IIα major histocompatibility-linked markers in salmon.Heredity · 2011Article
- Polymorphism and Balancing Selection of MHC Class II DAB Gene in 7 Selective Flounder (Paralichthys olivaceus) Families.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Allelic variation, balancing selection and positive selected sites detected from MHC class Iα gene of olive flounder.Genetica · 2010Article
- MHC evolution in three salmonid species: a comparison between class II alpha and beta genes.Immunogenetics · 2010Article
- Article
- MHC-mediated mate choice increases parasite resistance in salmon.Proceedings. Biological sciences · 2008Article
- MH class IIalpha polymorphism in local and global adaptation of Arctic charr (Salvelinus alpinus L.).Immunogenetics · 2008Article
- Multiple expressed MHC class II loci in salmonids; details of one non-classical region in Atlantic salmon (Salmo salar).BMC genomics · 2008Article
- Characterization, polymorphism, and evolution of MHC class II B genes in birds of prey.Journal of molecular evolution · 2007Article
- Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild.Proceedings. Biological sciences · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to investigate the mechanisms creating and maintaining variability at the major histocompatibility (MH) class II alpha (DAA) locus we examined patterns of polymorphism in two isolated Atlantic salmon populations which share a common post-glacial origin. As expected from their common origin, but contrary to the observation at the MH class I locus, these populations shared the majority of DAA alleles: out of 17 sequences observed, 11 were common to both populations. Recombination seems to play a more important role in the origin of new alleles at the class II alpha locus than at the class I locus. A greater than expected proportion of sites inferred to be positively selected (potentially peptide binding residues, PBRs) were found to be involved in recombination events, suggesting a mechanism for increasing MH variability through an interaction between recombination and natural selection. Thus it appears that although selection and recombination are important mechanisms for the evolution of both class II alpha and class I loci in the Atlantic salmon, the pattern of variability differs markedly between these classes of MH loci.
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