Trial reportBritish journal of cancer2005
Randomised controlled trial of mammographic screening in women from age 40: predicted mortality based on surrogate outcome measures.
Trial report in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Is there excess mortality in women screened with mammography: a meta-analysis of non-breast cancer mortality.Trials · 2013Pooled it
- Screening for breast cancer with mammography.The Cochrane database of systematic reviews · 2013Pooled it
- Randomised controlled trial of mammographic screening in women from age 40: results of screening in the first 10 years.British journal of cancer · 2005Trial
- The OncoSim-Breast Cancer Microsimulation Model.Current oncology (Toronto, Ont.) · 2022Article
- Final Results of the Prospective FH02 Mammographic Surveillance Study of Women Aged 35-39 at Increased Familial Risk of Breast Cancer.EClinicalMedicine · 2019Article
- Overdiagnosis in the population-based organized breast cancer screening program estimated by a non-homogeneous multi-state model: a cohort study using individual data with long-term follow-up.Breast cancer research : BCR · 2018Article
- Observed and Predicted Risk of Breast Cancer Death in Randomized Trials on Breast Cancer Screening.PloS one · 2016Article
- Breast cancer: Doubtful health benefit of screening from 40 years of age.Nature reviews. Clinical oncology · 2015Article
- Beyond the mammography debate: a moderate perspective.Current oncology (Toronto, Ont.) · 2015Article
- Mammographic surveillance in women aged 35-39 at enhanced familial risk of breast cancer (FH02).Familial cancer · 2014Article
- Choices for young women at intermediate risk of breast cancer.Current oncology (Toronto, Ont.) · 2012Article
- Screening mammography for women aged 40 to 49 years at average risk for breast cancer: an evidence-based analysis.Ontario health technology assessment series · 2007Article
- The patient experience.Breast cancer research and treatment · 2007Review
- Design of cancer screening trials/randomized trials for evaluation of cancer screening.World journal of surgery · 2006Review
- Screening mammography in women aged 40-49: is it time to change?International seminars in surgical oncology : ISSO · 2006Article
- Mammographic screening before age 50 years in the UK: comparison of the radiation risks with the mortality benefits.British journal of cancer · 2005Article
- Overdiagnosis and overtreatment of breast cancer: overdiagnosis in randomised controlled trials of breast cancer screening.Breast cancer research : BCR · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A trial in the UK to study the effect on mortality from breast cancer of invitation for annual mammography from the age of 40-41, has randomised a total of 160 921 women in the ratio 1 : 2 to the intervention and control arms. All breast cancers diagnosed in the two arms have been identified, and the histology reviewed. This paper presents the results of an interim analysis using surrogate outcome measures to compare predicted breast cancer mortality in the two arms based on 1287 cases diagnosed to 31.12.1999. Due to earlier diagnosis, there is currently an 8% excess of invasive breast cancers in the intervention arm. The ratio of predicted deaths at 10 years in the intervention arm relative to the control arm, adjusted for this excess diagnosis, ranges from 0.89 (95% confidence interval (CI) 0.78-1.01) to 0.90 (95% CI 0.80-1.01). Screening from age 40 may result in a lower reduction in breast cancer mortality than that observed in other trials including women below age 50. This analysis based on surrogate outcome measures suggests that a reduction in breast cancer mortality may be observed in this trial. However, a number of assumptions have been necessary and firm conclusions must await the analysis of observed mortality from breast cancer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.