Trial reportBritish journal of cancer2005
Randomised controlled trial of mammographic screening in women from age 40: results of screening in the first 10 years.
Trial report in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Screening for breast cancer with mammography.The Cochrane database of systematic reviews · 2013Pooled it
- Annual mammographic screening to reduce breast cancer mortality in women from age 40 years: long-term follow-up of the UK Age RCT.Health technology assessment (Winchester, England) · 2020Trial
- Modelling the overdiagnosis of breast cancer due to mammography screening in women aged 40 to 49 in the United Kingdom.Breast cancer research : BCR · 2012Trial
- Randomised controlled trial of mammographic screening in women from age 40: predicted mortality based on surrogate outcome measures.British journal of cancer · 2005Trial
- Comparing CISNET Breast Cancer Incidence and Mortality Predictions to Observed Clinical Trial Results of Mammography Screening from Ages 40 to 49.Medical decision making : an international journal of the Society for Medical Decision Making · 2018Article
- Towards personalized screening: Cumulative risk of breast cancer screening outcomes in women with and without a first-degree relative with a history of breast cancer.International journal of cancer · 2016Article
- Beyond the mammography debate: a moderate perspective.Current oncology (Toronto, Ont.) · 2015Article
- Mammography in asymptomatic women aged 40-49 years.Revista de saude publica · 2014Article
- Article
- Age-specific interval breast cancers in Japan: estimation of the proper sensitivity of screening using a population-based cancer registry.Cancer science · 2008Article
- Participation in mammography screening.BMJ (Clinical research ed.) · 2007Article
- Screening mammography for women aged 40 to 49 years at average risk for breast cancer: an evidence-based analysis.Ontario health technology assessment series · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Debate continues over the effectiveness of screening by mammography in women below age 50. We report here on results of screening in the first 10 years of a randomised trial to study the effect on breast cancer mortality of invitation to annual mammography from age 40 to 41 compared to first invitation to the 3-yearly UK national programme at age 50-52. The trial is taking place in 23 NHS breast screening centres. Between 1991 and 1997, 160 921 women were randomised in the ratio 1 : 2 to intervention and control arms. Screening is by two views at first screen and single view subsequently; data on screening up to and including round five are now complete. Uptake of invitation to screening is between 68 and 70% at all but the latest screening rounds. Rates of referral for assessment are 4.6% at first screen and 3.4% at subsequent screens. Invasive cancer detection rates are 0.09% at first screen, and similar at rescreens until the sixth and later screens. There is little evidence of regular mammography in the trial control arm. The setting of this trial within the NHS breast screening programme should ensure applicability of results to a national programme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.