ArticleThe Biochemical journal2005
Gene duplication, gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family.
Article in The Biochemical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Regulation of the amh gene promoter activity by SF-1 in sex-reversing Cheilinus undulatus and its adaptive evolution.BMC genomics · 2026Article
- Sex- and stage-dependent expression of gonadal soma-derived factor paralogues reveals functional and evolutionary divergence in European sea bass (Frontiers in endocrinology · 2026Article
- Direct male development in chromosomally ZZ zebrafish.Frontiers in cell and developmental biology · 2024Article
- Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis.PLoS genetics · 2022Article
- Sex-specific splicing of Z- and W-borneProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- A fish with no sex: gonadal and adrenal functions partition between zebrafish NR5A1 co-orthologs.Genetics · 2021Article
- Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function.Human molecular genetics · 2017Article
- Rx3 and Shh direct anisotropic growth and specification in the zebrafish tuberal/anterior hypothalamus.Development (Cambridge, England) · 2016Article
- Two Zebrafish hsd3b Genes Are Distinct in Function, Expression, and Evolution.Endocrinology · 2015Article
- Molecular cloning and sexually dimorphic expression patterns of nr0b1 and nr5a2 in olive flounder, Paralichthys olivaceus.Development genes and evolution · 2015Article
- Dicer deficiency reveals microRNAs predicted to control gene expression in the developing adrenal cortex.Molecular endocrinology (Baltimore, Md.) · 2013Article
- An SNP-Based Linkage Map for Zebrafish Reveals Sex Determination Loci.G3 (Bethesda, Md.) · 2011Article
- Molecular cloning and expression analysis of fushi tarazu factor 1 in the brain of air-breathing catfish, Clarias gariepinus.PloS one · 2011Article
- Temporal and spatial expression of CCN genes in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- DiRE: identifying distant regulatory elements of co-expressed genes.Nucleic acids research · 2008Article
- Paralogous vitamin D receptors in teleosts: transition of nuclear receptor function.Endocrinology · 2008Article
- The olig family: phylogenetic analysis and early gene expression in Xenopus tropicalis.Development genes and evolution · 2007Article
- Interrenal organogenesis in the zebrafish model.Organogenesis · 2007Article
- Zebrafish sex determination and differentiation: involvement of FTZ-F1 genes.Reproductive biology and endocrinology : RB&E · 2005Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Fushi tarazu factor 1 (Ftz-F1, NR5A) is a zinc-finger transcription factor that belongs to the nuclear receptor superfamily and regulates genes that are involved in sterol and steroid metabolism in gonads, adrenals, liver and other tissues. To understand the evolutionary origins and developmental genetic relationships of the Ftz-F1 genes, we have cloned four homologous Ftz-f1 genes in zebrafish, called ff1a, ff1b, ff1c and ff1d. These four genes have different temporal and spatial expression patterns during development, indicating that they have distinct mechanisms of genetic regulation. Among them, the ff1a expression pattern is similar to mammalian Nr5a2, while the ff1b pattern is similar to that of mammalian Nr5a1. Genetic mapping experiments show that these four ff1 genes are located on chromosome segments conserved between the zebrafish and human genomes, indicating a common ancestral origin. Phylogenetic and conserved synteny analysis show that ff1a is the orthologue of NR5A2, and that ff1b and ff1d genes are co-orthologues of NR5A1 that arose by a gene-duplication event, probably a whole-genome duplication, in the ray-fin lineage, and each gene is located next to an NR6A1 co-orthologue as in humans, showing that the tandem duplication occurred before the divergence of human and zebrafish lineages. ff1c does not have a mammalian counterpart. Thus we have characterized the phylogenetic relationships, expression patterns and chromosomal locations of these Ftz-F1 genes, and have demonstrated their identities as NR5A genes in relation to the orthologous genes in other species.
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