ReviewProstate cancer and prostatic diseases2005
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
Review in Prostate cancer and prostatic diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 121 citations in OpenAlex.
- Bortezomib-mediated inhibition of steroid receptor coactivator-3 degradation leads to activated Akt.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Trial
- Review
- Introducing Aurora Kinase A as a Gene Target Against Photoaging: A Network Analysis.Journal of lasers in medical sciences · 2025Article
- Loss of phosphatase and tensin homolog expression castration-sensitive prostate cancer predicts outcomes in men after prostatectomy.International journal of urology : official journal of the Japanese Urological Association · 2025Article
- Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory programs.Biomaterials · 2024Article
- Raloxifene Suppresses Tumor Growth and Metastasis in an Orthotopic Model of Castration-Resistant Prostate Cancer.Biomedicines · 2022Article
- Overview of the Development and Use of Akt Inhibitors in Prostate Cancer.Journal of clinical medicine · 2021Review
- microRNA-mediatedExperimental and therapeutic medicine · 2019Article
- TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells.Molecular oncology · 2018Article
- Long non-coding RNA NAP1L6 promotes tumor progression and predicts poor prognosis in prostate cancer by targeting Inhibin-β A.OncoTargets and therapy · 2018Article
- Gene polymorphisms in the PI3K/AKT/mTOR signaling pathway contribute to prostate cancer susceptibility in Chinese men.Oncotarget · 2017Article
- A single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17.Scientific reports · 2017Article
- Versatile Functions of Caveolin-1 in Aging-related Diseases.Chonnam medical journal · 2017Review
- Overexpression of long non-coding RNA LOC400891 promotes tumor progression and poor prognosis in prostate cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Inflammatory Responses in a Benign Prostatic Hyperplasia Epithelial Cell Line (BPH-1) Infected with Trichomonas vaginalis.The Korean journal of parasitology · 2016Article
- Computational Reconstruction of NFκB Pathway Interaction Mechanisms during Prostate Cancer.PLoS computational biology · 2016Article
- Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling.Molecular carcinogenesis · 2015Article
- Prognostic value of caveolin-1 in genitourinary cancer: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- PTEN genomic deletion defines favorable prognostic biomarkers in localized prostate cancer: a systematic review and meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Enhanced antitumor effects of low-frequency ultrasound and microbubbles in combination with simvastatin by downregulating caveolin-1 in prostatic DU145 cells.Oncology letters · 2014Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The PI3-K-Akt pathway plays a central role in the development and progression of prostate cancer and other malignancies. We review original studies and summarize relevant sections of previous reviews concerning the relationships between abnormalities in the PI3-K-Akt pathway and prostate cancer progression. We discuss laboratory and clinical data that indicate gene perturbation and dysregulation of PI3-K-Akt pathway is common in prostate cancer and other malignancies. We further discuss the critical role of the PI3-K-Akt pathway in the oncogenic signaling network and provide examples that establish the PI3-K-Akt pathway as a focal point for the future development of informative biomarkers and effective therapies for prostate cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.