Trial reportMolecular psychiatry2005
Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls.
Trial report in Molecular psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00161161 (Genetic Liability in the Brain Morphology of Attention Deficit Hyperactivity Disorder), which is not on this map. Cited by 80 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Liability in the Brain Morphology of Attention Deficit Hyperactivity Disorder
Who cites it
80 citing papers in PubMed, 3 syntheses or guidelines pooled it, 218 citations in OpenAlex.
- Brain imaging genetics in ADHD and beyond - Mapping pathways from gene to disorder at different levels of complexity.Neuroscience and biobehavioral reviews · 2017Pooled it
- Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects.Brain imaging and behavior · 2013Pooled it
- Structural brain change in Attention Deficit Hyperactivity Disorder identified by meta-analysis.BMC psychiatry · 2008Pooled it
- Genetic variation in the dopamine D4 receptor (DRD4) gene and smoking cessation: follow-up of a randomised clinical trial of transdermal nicotine patch.The pharmacogenomics journal · 2008Trial
- Development of cognitive control and executive functions from 4 to 13 years: evidence from manipulations of memory, inhibition, and task switching.Neuropsychologia · 2006Trial
- Heritability of cognitive abilities and regional brain structures in middle-aged to elderly East Asians.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Early musical training benefits to non-musical cognitive ability associated with the Gestalt principles.Frontiers in psychology · 2023Article
- Methylphenidate as a treatment option for substance use disorder: a transdiagnostic perspective.Frontiers in psychiatry · 2023Article
- Preserved Motility after Neonatal Dopaminergic Lesion Relates to Hyperexcitability of Direct Pathway Medium Spiny Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder.Translational psychiatry · 2021Review
- First Demonstration of Double Dissociation between COMT-Met158 and COMT-Val158 Cognitive Performance When Stressed and When Calmer.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Rostral Anterior Cingulate Thickness Predicts the Emotional Psilocybin Experience.Biomedicines · 2020Article
- Parenting Practices and Adolescent Effortful Control:Frontiers in psychology · 2020Article
- Putamen gray matter volumes in neuropsychiatric and neurodegenerative disorders.World journal of psychiatry and mental health research · 2019Article
- Reduced Prefrontal Gyrification in Carriers of the Dopamine D4 Receptor 7-Repeat Allele With Attention Deficit/Hyperactivity Disorder: A Preliminary Report.Frontiers in psychiatry · 2019Article
- Dopamine D4 Receptor Gene Associated with the Frontal-Striatal-Cerebellar Loop in Children with ADHD: A Resting-State fMRI Study.Neuroscience bulletin · 2018Article
- Effects of the 2-Repeat Allele of the DRD4 Gene on Neural Networks Associated With the Prefrontal Cortex in Children With ADHD.Frontiers in human neuroscience · 2018Article
- The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users.Cannabis and cannabinoid research · 2018Article
- Imaging genetics in neurodevelopmental psychopathology.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Effects of dopaminergic genes, prenatal adversities, and their interaction on attention-deficit/hyperactivity disorder and neural correlates of response inhibition.Journal of psychiatry & neuroscience : JPN · 2017Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic influences on behavior are complex and, as such, the effect of any single gene is likely to be modest. Neuroimaging measures may serve as a biological intermediate phenotype to investigate the effect of genes on human behavior. In particular, it is possible to constrain investigations by prior knowledge of gene characteristics and by including samples of subjects where the distribution of phenotypic variance is both wide and under heritable influences. Here, we use this approach to show a dissociation between the effects of two dopamine genes that are differentially expressed in the brain. We show that the DAT1 gene, a gene expressed predominantly in the basal ganglia, preferentially influences caudate volume, whereas the DRD4 gene, a gene expressed predominantly in the prefrontal cortex, preferentially influences prefrontal gray matter volume in a sample of subjects including subjects with ADHD, their unaffected siblings, and healthy controls. This demonstrates that, by constraining our investigations by prior knowledge of gene expression, including samples in which the distribution of phenotypic variance is wide and under heritable influences, and by using intermediate phenotypes, such as neuroimaging, we may begin to map out the pathways by which genes influence behavior.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.