Evidence map›Paper›PMID 15724037›Full record

ArticleArchives of disease in childhood. Fetal and neonatal edition2005

The EPICure study: associations and antecedents of neurological and developmental disability at 30 months of age following extremely preterm birth.

N S Wood, K Costeloe, A T Gibson, E M Hennessy, N Marlow, A R Wilkinson, EPICure Study Group

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PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of disease in childhood. Fetal and neonatal edition, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 10 pooled it
36.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 10 syntheses or guidelines pooled it, 422 citations in OpenAlex.

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  2. Inhaled nitric oxide for respiratory failure in preterm infants.The Cochrane database of systematic reviews · 2017
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76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

N S WoodAcademic Division of Child Health, Level E East Block, Queens Medical Centre, Nottingham NG7 2UH, UK.
K Costeloe
A T Gibson
E M Hennessy
N Marlow
A R Wilkinson
EPICure Study Group
Queen Mary University of London · GBQueen's Medical Centre · GBRoyal Hallamshire Hospital · GBUniversity of Nottingham · GBUniversity of Oxford · GB

Funding

Medical Research Council G0401525
6 · The paper itself

Abstract

aimsTo describe perinatal factors associated with later morbidity among extremely preterm children at 30 months of age corrected for prematurity. POPULATION: Of 308 surviving children born at <or=25 weeks gestation in the United Kingdom and Ireland from March to December 1995, 283 (92%) were evaluated at 30 months of age corrected for prematurity.

methodsCerebral palsy, severe motor disability, and Bayley scores were used as dependent variables in sequential multiple regression analyses to identify factors associated with adverse outcomes.

resultsAdverse outcomes were consistently more common in boys. Factors related to perinatal illness, ultrasound evidence of brain injury, and treatment (particularly postnatal steroids) were associated with adverse motor outcomes (cerebral palsy, disability or Bayley psychomotor development index). Increasing duration of postnatal steroid treatment was associated with poor motor outcomes. A score was developed for severe motor disability with good negative predictive value. In contrast, mental development was associated with a broader range of factors: ethnic group, maternal educational level, the use of antenatal steroids, and prolonged rupture of membranes in addition to chronic lung disease.

conclusionMale sex is a pervasive risk factor for poor outcome at extremely low gestations. Avoidable or effective treatment factors are identified, which may indicate the potential for improving outcome.

Indexed as

Infant, PrematureCerebral PalsyChild, PreschoolCognition DisordersCohort StudiesDevelopmental DisabilitiesFemaleGestational AgeHumansInfant, NewbornMaleMorbidityMovement DisordersPrognosisPsychomotor DisordersRegression AnalysisSteroids

Identifiers

PMID15724037
PMCPMC1721849
OpenAlexW2032786136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.