ArticleNature structural & molecular biology2005
Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation.
Article in Nature structural & molecular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 196 citations in OpenAlex.
- A magic methyl effect in the active site of a methyltransferase ribozyme.Nature communications · 2026Article
- Epoxy tetrahydrophthalimides as potential bioactive agents: synthesis and computational study.Pest management science · 2025Article
- Recent advances in enzymatic carbon-carbon bond formation.RSC advances · 2024Review
- Nucleotides Entrapped in Liposome Nanovesicles as Tools for Therapeutic and Diagnostic Use in Biomedical Applications.Pharmaceutics · 2023Review
- Revisiting the Extinction of the RNA World.Biochemistry · 2022Review
- Structure and mechanism of a methyltransferase ribozyme.Nature chemical biology · 2022Article
- A new RNA performs old chemistry.Nature chemical biology · 2022Article
- Structure and mechanism of the methyltransferase ribozyme MTR1.Nature chemical biology · 2022Article
- Optimized Biocatalytic Synthesis of 2-Selenopyrimidine Nucleosides by Transglycosylation*.Chembiochem : a European journal of chemical biology · 2021Article
- Aptamers, Riboswitches, and Ribozymes inLife (Basel, Switzerland) · 2021Review
- A Cu(II)-ATP complex efficiently catalyses enantioselective Diels-Alder reactions.Nature communications · 2020Article
- Molecular simulations of the pistol ribozyme: unifying the interpretation of experimental data and establishing functional links with the hammerhead ribozyme.RNA (New York, N.Y.) · 2019Article
- Probing G-quadruplex topologies and recognition concurrently in real time and 3D using a dual-app nucleoside probe.Nucleic acids research · 2019Article
- Structure of the Ribosomal RNA Decoding Site Containing a Selenium-Modified Responsive Fluorescent Ribonucleoside Probe.Angewandte Chemie (International ed. in English) · 2017Article
- MIPs and Aptamers for Recognition of Proteins in Biomimetic Sensing.Biosensors · 2016Review
- Recent advances of Diels-Alderases involved in natural product biosynthesis.The Journal of antibiotics · 2016Review
- DNA Catalysis: The Chemical Repertoire of DNAzymes.Molecules (Basel, Switzerland) · 2015Review
- Fitness Landscapes of Functional RNAs.Life (Basel, Switzerland) · 2015Review
- The importance of fitting in: conformational preference of selenium 2' modifications in nucleosides and helical structures.Journal of biomolecular structure & dynamics · 2015Article
- Nucleic acid catalysis: metals, nucleobases, and other cofactors.Chemical reviews · 2014Review
5 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
The majority of structural efforts addressing RNA's catalytic function have focused on natural ribozymes, which catalyze phosphodiester transfer reactions. By contrast, little is known about how RNA catalyzes other types of chemical reactions. We report here the crystal structures of a ribozyme that catalyzes enantioselective carbon-carbon bond formation by the Diels-Alder reaction in the unbound state and in complex with a reaction product. The RNA adopts a lambda-shaped nested pseudoknot architecture whose preformed hydrophobic pocket is precisely complementary in shape to the reaction product. RNA folding and product binding are dictated by extensive stacking and hydrogen bonding, whereas stereoselection is governed by the shape of the catalytic pocket. Catalysis is apparently achieved by a combination of proximity, complementarity and electronic effects. We observe structural parallels in the independently evolved catalytic pocket architectures for ribozyme- and antibody-catalyzed Diels-Alder carbon-carbon bond-forming reactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.