ArticleNucleic acids research2005
The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expression.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Angiogenin mediates cell-cell fusion as a mitochondrial RNA processing enzyme.Bone research · 2026Article
- Genetic background and oncogenic driver determines the genomic evolution and transcriptomics of mammary tumor metastasis.Communications biology · 2025Article
- Investigating the genomic landscape of mouse models of breast cancer metastasis.bioRxiv : the preprint server for biology · 2025Article
- Assay for ribosome stimulation of angiogenin nuclease activity.Methods in enzymology · 2025Article
- Ribonucleases of Mice and Men: Unveiling the Roles of the RNase A Superfamily in Host Defence.Journal of immunology research · 2025Review
- Functional Insight into hTRIR.Current molecular medicine · 2024Article
- Ribonuclease 4 is associated with aggressiveness and progression of prostate cancer.Communications biology · 2022Article
- Expression and function of human ribonuclease 4 in the kidney and urinary tract.American journal of physiology. Renal physiology · 2021Article
- Angiogenin maintains gut microbe homeostasis by balancing α-Proteobacteria and Lachnospiraceae.Gut · 2021Article
- Physiologic RNA targets and refined sequence specificity of coronavirus EndoU.RNA (New York, N.Y.) · 2020Article
- Angiogenin and tRNA fragments in Parkinson's disease and neurodegeneration.Acta pharmacologica Sinica · 2020Review
- Phenotype of ribonuclease 1 deficiency in mice.RNA (New York, N.Y.) · 2019Article
- The Immunomodulatory and Antimicrobial Properties of the Vertebrate Ribonuclease A Superfamily.Vaccines · 2018Review
- Abundance of RNase4 and RNase5 mRNA and protein in host defence related tissues and secretions in cattle.Biochemistry and biophysics reports · 2016Article
- Three decades of research on angiogenin: a review and perspective.Acta biochimica et biophysica Sinica · 2016Review
- Mechanism and Function of Angiogenin in Prostate Cancer.Zhongguo sheng wu hua xue yu fen zi sheng wu xue bao = Chinese journal of biochemistry and molecular biology · 2015Article
- Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop.The Journal of biological chemistry · 2014Article
- Genes of the RNASE5 pathway contain SNP associated with milk production traits in dairy cattle.Genetics, selection, evolution : GSE · 2013Article
- Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress.Angiogenesis · 2013Article
- Angiogenin cleaves tRNA and promotes stress-induced translational repression.The Journal of cell biology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The ribonuclease A (RNase A) superfamily has been the subject of extensive studies in the areas of protein evolution, structure and biochemistry and are exciting molecules in that they appear to be responding to unique selection pressures, generating proteins capable of multiple and diverse activities. The RNase 4 and RNase 5/ang 1 shared locus breaks a pattern that is otherwise canonical among the members of the RNase A gene superfamily. Conserved among humans, mice and rats, the locus includes two non-coding exons followed by two distinct exons encoding RNase 4 and RNase 5/ang 1. Transcription from this locus is controlled by differential splicing and tissue-specific expression from promoters located 5' to each of the non-coding exons. Promoter 1, 5' to exon I, is universally active, while Promoter 2, 5' to exon II, is active only in hepatic cells in promoter assays in vitro. Transcription from Promoter 2 is dependent on an intact HNF-1 consensus binding site which binds the transcription factor HNF-1alpha. In summary, RNase 4 and RNase 5/ang 1 are unique among the RNase A ribonuclease genes in that they maintain a complex gene locus that is conserved across species with transcription initiated from tissue-specific dual promoters followed by differential exon splicing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.