ArticleThe Plant cell2005
The Arabidopsis GAMYB-like genes, MYB33 and MYB65, are microRNA-regulated genes that redundantly facilitate anther development.
Article in The Plant cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 336 papers.
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336 citing papers in PubMed, 694 citations in OpenAlex.
- VvGAMYB Orchestrates Multi-Signaling Networks to Modulate GA-Induced Parthenocarpic Seedless Berry Development in Grapes.International journal of molecular sciences · 2026Article
- Heat stress-induced remodelling of lipid and microRNA networks in Brassica napus germinated pollen and pollen-derived small extracellular vesicles.Journal of experimental botany · 2026Article
- Molecular understanding of plant pollination, fertilization, seed development and protoplast regeneration.Science China. Life sciences · 2026Review
- Functional divergence of MADS-box genes and the dual regulatory role of a long noncoding RNA underlie sex determination in Ginkgo biloba.BMC plant biology · 2026Article
- Transcriptome Analysis Reveals the Involvement ofBiology · 2026Article
- Genome-Wide Study of MYB Transcription Factors in Maize and Their Essential Roles in Male Fertility and Other Biological Processes.International journal of molecular sciences · 2026Article
- The post-fertilization archegonium gene network of seedless plants contributed to the origin of seeds.Nature communications · 2026Article
- MYB regulator of "colorless" flavonols underlies the evolution of red flowers in Iochroma (Solanaceae).G3 (Bethesda, Md.) · 2025Article
- Single-Cell Transcriptome Atlas and Dynamic Regulatory Mechanisms of Anther Development in Alfalfa (Medicago sativa L.).Plant biotechnology journal · 2025Article
- Identification of Key Regulators of Plant Height Variation and Stress Tolerance of the RcMYB Family inInternational journal of molecular sciences · 2025Article
- The basic helix-loop-helix (bHLH) transcription factor DTT1 is part of a paired key that unlocks the tapetum transition in barley anther development.The Plant cell · 2025Article
- Unraveling the Multilayered Regulatory Networks of miRNAs and PhasiRNAs inPlants (Basel, Switzerland) · 2025Article
- Genome-wide identification of the Medicago sativa L. MYB family and its transcriptional dynamics during pollen development.BMC plant biology · 2025Article
- Dynamics of small RNAs in a red-fruited wine grape cultivar infected with Grapevine red blotch virus.BMC genomics · 2025Article
- Advances in Small RNA Regulation of Female Gametophyte Development in Flowering Plants.Plants (Basel, Switzerland) · 2025Review
- Identity Transitions of Tapetum Phases: Insights into Vesicular Dynamics and in Mortem Support During Pollen Maturation.Plants (Basel, Switzerland) · 2025Review
- LoBLH6 interacts with LoMYB65 to regulate anther development through feedback regulation of gibberellin synthesis in lily.Horticulture research · 2025Article
- Overexpression ofInternational journal of molecular sciences · 2025Article
- Deciphering the impact of microRNAs in plant biology: a review of computational insights and experimental validation.Molecular biology reports · 2025Review
- Global identification and regulatory network analysis reveal the significant roles of lncRNAs during anther and pollen development in Arabidopsis.Plant cell reports · 2025Article
276 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
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Abstract
The functions of the vast majority of genes encoding R2R3 MYB domain proteins remain unknown. The closely related MYB33 and MYB65 genes of Arabidopsis thaliana have high sequence similarity to the barley (Hordeum vulgare) GAMYB gene. T-DNA insertional mutants were isolated for both genes, and a myb33 myb65 double mutant was defective in anther development. In myb33 myb65 anthers, the tapetum undergoes hypertrophy at the pollen mother cell stage, resulting in premeiotic abortion of pollen development. However, myb33 myb65 sterility was conditional, where fertility increased both under higher light or lower temperature conditions. Thus, MYB33/MYB65 facilitate, but are not essential for, anther development. Neither single mutant displayed a phenotype, implying that MYB33 and MYB65 are functionally redundant. Consistent with functional redundancy, promoter-beta-glucuronidase (GUS) fusions of MYB33 and MYB65 gave identical expression patterns in flowers (sepals, style, receptacle, anther filaments, and connective but not in anthers themselves), shoot apices, and root tips. By contrast, expression of a MYB33:GUS translational fusion in flowers was solely in young anthers (consistent with the male sterile phenotype), and no staining was seen in shoot meristems or root tips. A microRNA target sequence is present in the MYB genes, and mutating this sequence in the MYB33:GUS fusion results in an expanded expression pattern, in tissues similar to that observed in the promoter-GUS lines, implying that the microRNA target sequence is restricting MYB33 expression. Arabidopsis transformed with MYB33 containing the mutated microRNA target had dramatic pleiotrophic developmental defects, suggesting that restricting MYB33 expression, especially in the shoot apices, is essential for proper plant development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.