ArticleBiophysical journal2005
Structure and dynamics of model pore insertion into a membrane.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 58 citations in OpenAlex.
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- Applications of cyclic peptide nanotubes (cPNTs).Journal of food and drug analysis · 2019Review
- Role of metal oxide nanoparticles in histopathological changes observed in the lung of welders.Particle and fibre toxicology · 2014Article
- Aggregation of model membrane proteins, modulated by hydrophobic mismatch, membrane curvature, and protein class.Biophysical journal · 2011Article
- Interaction of diverse voltage sensor homologs with lipid bilayers revealed by self-assembly simulations.Biophysical journal · 2011Article
- The energetics of transmembrane helix insertion into a lipid bilayer.Biophysical journal · 2010Article
- Synthetic chloride-selective carbon nanotubes examined by using molecular and stochastic dynamics.Biophysical journal · 2010Article
- Coarse-grained molecular dynamics of tetrameric transmembrane peptide bundles within a lipid bilayer.Chemistry and physics of lipids · 2010Article
- Peptide nanopores and lipid bilayers: interactions by coarse-grained molecular-dynamics simulations.Biophysical journal · 2009Article
- Modeling Transport Through Synthetic Nanopores.IEEE nanotechnology magazine · 2009Article
- Orientation of the monomeric porin OmpG in planar lipid bilayers.Chembiochem : a European journal of chemical biology · 2008Article
- Coarse-grained simulation studies of peptide-induced pore formation.Biophysical journal · 2008Article
- Simulations of electrophoretic RNA transport through transmembrane carbon nanotubes.Biophysical journal · 2008Article
- Computational modeling of poly(alkylthiophene) conductive polymer insertion into phospholipid bilayers.Langmuir : the ACS journal of surfaces and colloids · 2007Article
- Coarse grained protein-lipid model with application to lipoprotein particles.The journal of physical chemistry. B · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
A cylindrical transmembrane molecule is constructed by linking hydrophobic sites selected from a coarse grain model. The resulting hollow tube assembly serves as a representation of a transmembrane channel, pore, or a carbon nanotube. The interactions of a coarse grain di-myristoyl-phosphatidyl-choline hydrated bilayer with both a purely hydrophobic tube and a tube with hydrophilic caps are studied. The hydrophobic tube rotates in the membrane and becomes blocked by lipid tails after a few tens of nanoseconds. The hydrophilic sites of the capped tube stabilize it by anchoring the tube in the lipid headgroup/water interfacial region of each membrane leaflet. The capped tube remains free of lipid tails. The capped tube spontaneously conducts coarse grain water sites; the free-energy profile of this process is calculated using three different methods and is compared to the barrier for water permeation through the lipid bilayer. Spontaneous tube insertion into an undisturbed lipid bilayer is also studied, which we reported briefly in a previous publication. The hydrophobic tube submerges into the membrane core in a carpetlike manner. The capped tube laterally fuses with the closest leaflet, and then, after plunging into the membrane interior, rotates to assume a transbilayer orientation. Two lipids become trapped at the end of the tube as it penetrates the membrane. The hydrophilic headgroups of these lipids associate with the lower tube cap and assist the tube in crossing the interior of the membrane. When the rotation is complete these lipids detach from the tube caps and fuse with the lower leaflet lipids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.