SynthesisThe British journal of general practice : the journal of the Royal College of General Practitioners2005
The effectiveness of community maintenance with methadone or buprenorphine for treating opiate dependence.
Synthesis in The British journal of general practice : the journal of the Royal College of General Practitioners, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Homelessness and health-related outcomes: an umbrella review of observational studies and randomized controlled trials.BMC medicine · 2022Pooled it
- Clinical guideline for homeless and vulnerably housed people, and people with lived homelessness experience.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020Guideline
- Pooled it
- Opioid dependence.BMJ clinical evidence · 2011Pooled it
- Opioid dependence.BMJ clinical evidence · 2009Pooled it
- Patients' experiences of continued treatment with extended-release naltrexone: a Norwegian qualitative study.Addiction science & clinical practice · 2022Trial
- Buprenorphine versus dihydrocodeine for opiate detoxification in primary care: a randomised controlled trial.BMC family practice · 2007Trial
- Behavior change, health, and health disparities 2023: Contingency management for treating substance use disorders and promoting health in vulnerable populations.Preventive medicine · 2023Article
- Predicting premature discontinuation of medication for opioid use disorder from electronic medical records.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2023Article
- Comparison of Lapse Rate in Drug Dependent Patients in 2 Methods of Methadone Maintenance Treatment and Buprenorphine Maintenance Treatment.Substance abuse : research and treatment · 2022Article
- Factors That Affect Patient Attrition in Buprenorphine Treatment for Opioid Use Disorder: A Retrospective Real-World Study Using Electronic Health Records.Neuropsychiatric disease and treatment · 2021Article
- Article
- Medication for opioid use disorder treatment and specialty outpatient substance use treatment outcomes: Differences in retention and completion among opioid-related discharges in 2016.Journal of substance abuse treatment · 2020Article
- Factors associated with methadone maintenance therapy discontinuation among people who inject drugs.Journal of substance abuse treatment · 2018Article
- The Future of Opioid Agonist Therapies in Ukraine: A Qualitative Assessment of Multilevel Barriers and Ways Forward to Promote Retention in Treatment.Journal of substance abuse treatment · 2016Article
- Drug addiction stigma in relation to methadone maintenance treatment by different service delivery models in Vietnam.BMC public health · 2016Article
- Entry into primary care-based buprenorphine treatment is associated with identification and treatment of other chronic medical problems.Addiction science & clinical practice · 2012Article
- Buprenorphine: new treatment of opioid addiction in primary care.Canadian family physician Medecin de famille canadien · 2011Review
- Long-term outcomes of office-based buprenorphine/naloxone maintenance therapy.Drug and alcohol dependence · 2010Article
- Short-term outcomes in patients attending a primary care-based addiction shared care program.Canadian family physician Medecin de famille canadien · 2009Article
Corrections and comments
- Commented on by
- Commented on byQualifications.2005
- Commented on by
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOpiate dependence is a major health and social issue in many countries. A mainstay of therapy has been methadone maintenance treatment, but other treatments, particularly buprenorphine, are increasingly being considered.
aimTo conduct a systematic review to synthesise and critically appraise the evidence on the effectiveness of community maintenance programmes with methadone or buprenorphine in treating opiate dependence.
methodA systematic review of databases, journals and the grey literature was carried out from 1990-2002. Inclusion criteria were: community-based, randomised controlled trials of methadone and/or buprenorphine for opiate dependence involving subjects who were aged 18 years old or over.
resultsTrials were set in a range of countries, employed a variety of comparators, and suffered from a number of biases. The evidence indicated that higher doses of methadone and buprenorphine are associated with better treatment outcomes. Low-dose methadone (20 mg per day) is less effective than buprenorphine (2-8 mg per day). Higher doses of methadone (>50-65 mg per day) are slightly more effective than buprenorphine (2-8 mg per day). There was some evidence that primary care could be an effective setting to provide this treatment, but such evidence was sparse.
conclusionThe literature supports the effectiveness of substitute prescribing with methadone or buprenorphine in treating opiate dependence. Evidence is also emerging that the provision of methadone or buprenorphine by primary care physicians is feasible and may be effective.
Indexed as
Identifiers
15720937PMC1463190W2163464282What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.