ArticleClinical and experimental immunology1992
The profile of IgG and IgG subclasses of onchocerciasis patients.
Article in Clinical and experimental immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Diagnostic performance of Strongyloides-specific IgG4 detection in urine for diagnosis of human strongyloidiasis.Parasites & vectors · 2023Article
- Unraveling cross-reactivity of anti-glycan IgG responses in filarial nematode infections.Frontiers in immunology · 2023Article
- Onchocerciasis Fingerprints in the Geriatric Population: Does Host Immunity Play a Role?Tropical medicine and infectious disease · 2021Review
- Current Considerations for Immunoglobulin Isotype Characterization of Antibody Response against Biotherapeutics.The AAPS journal · 2020Review
- Article
- Identification of three immunodominant motifs with atypical isotype profile scattered over the Onchocerca volvulus proteome.PLoS neglected tropical diseases · 2017Article
- Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels.PLoS neglected tropical diseases · 2014Article
- IgG subclass responses to proinflammatory fraction of Brugia malayi in human filariasis.The Indian journal of medical research · 2012Article
- Induction of immunoglobulin G4 in human filariasis: an indicator of immunoregulation.Annals of tropical medicine and parasitology · 2010Review
- Differential cytokine and antibody responses to adult and larval stages of Onchocerca volvulus consistent with the development of concomitant immunity.Infection and immunity · 2002Article
- Tropomyosin implicated in host protective responses to microfilariae in onchocerciasis.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- The diverse expression of immunity in humans at distinct states of Onchocerca volvulus infection.Immunology · 1997Article
- The novel cuticular collagen Ovcol-1 of Onchocerca volvulus is preferentially recognized by immunoglobulin G3 from putatively immune individuals.Infection and immunity · 1997Article
- Immunoglobulin G subclass responses of children during infection with Onchocerca volvulus.Clinical and diagnostic laboratory immunology · 1996Article
- Recent advances in tropical medicine.BMJ (Clinical research ed.) · 1994Review
- Ivermectin-facilitated immunity in onchocerciasis; activation of parasite-specific Th1-type responses with subclinical Onchocerca volvulus infection.Clinical and experimental immunology · 1994Article
- The significance of blood levels of IgM, IgA, IgG and IgG subclasses in Sudanese visceral leishmaniasis patients.Clinical and experimental immunology · 1994Article
- Standardization: who wants it?Clinical and experimental immunology · 1992Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In this study Onchocerca gutturosa was compared with O. volvulus in an ELISA test to detect Onchocerca-specific IgG and IgG subclasses. The test was developed and standardized to detect Onchocerca-specific IgG and IgG subclasses in sera of onchocerciasis patients and endemic controls. Onchocerca volvulus and O. gutturosa crude water-soluble antigens showed no significant difference in detecting onchocerca-specific IgG antibody (T = 1.88, P greater than 0.05). The levels of IgG subclasses varied greatly. IgG4 showed the highest detected mean level (0.84 +/- 0.59) and the other three subclasses showed considerably lower mean levels (IgG1 = 0.27 +/- 0.16, IgG2 = 0.24 +/- 0.17, IgG3 = 0.28 +/- 0.12). The status and score of skin lesions were found to have significant effect on the IgG and IgG subclasses levels (all P less than 0.001). IgG4 showed a positive correlation with the microfilarial (Mf) load (r = 0.21, P less than 0.03). IgG3 levels have a significant negative correlation with the Mf load (r = -0.23, P less than 0.02). The biological significance of these IgG and IgG subclasses in onchocerciasis is discussed.
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Registered trials
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