ArticleNeoplasia (New York, N.Y.)
Monoclonal antibody 16D10 to the C-terminal domain of the feto-acinar pancreatic protein binds to membrane of human pancreatic tumoral SOJ-6 cells and inhibits the growth of tumor xenografts.
Article in Neoplasia (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2The Journal of biological chemistry · 2018Article
- Review
- Blind SELEX Approach Identifies RNA Aptamers That Regulate EMT and Inhibit Metastasis.Molecular cancer research : MCR · 2017Article
- A pancreatic tumor-specific biomarker characterized in humans and mice as an immunogenic onco-glycoprotein is efficient in dendritic cell vaccination.Oncotarget · 2015Article
- Exosomal lipids impact notch signaling and induce death of human pancreatic tumoral SOJ-6 cells.PloS one · 2012Article
- Investigation of a new tumor-associated glycosylated antigen as target for dendritic cell vaccination in pancreatic cancer.Oncoimmunology · 2012Article
- Therapeutic antibodies for the treatment of pancreatic cancer.TheScientificWorldJournal · 2010Review
- Cancer cell-derived microparticles bearing P-selectin glycoprotein ligand 1 accelerate thrombus formation in vivo.The Journal of experimental medicine · 2009Article
- Bile salt-dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans.The Journal of clinical investigation · 2007Article
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9 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Feto-acinar pancreatic protein (FAPP) characterized by mAbJ28 reactivity is a specific component associated with ontogenesis and behaves as an oncodevelopment-associated antigen. We attempted to determine whether pancreatic tumoral SOJ-6 cells are expressed at their surface FAPP antigens and to examine if specific antibodies directed against these FAPP epitopes could decrease the growth of pancreatic tumors in a mice model. For this purpose, we used specific antibodies against either the whole FAPP, the O-glycosylated C-terminal domain, or the N-terminal domain of the protein. Our results indicate that SOJ-6 cells expressed at their surface a 32-kDa peptide corresponding to the C-terminal domain of the FAPP. Furthermore, we show, by using endoproteinase Lys-C or geldanamycin, a drug able to impair the FAPP secretion, that this 32-kDa peptide expressed on the SOJ-6 cell surface comes from the degradation of the FAPP. Finally, an in vivo prospective study using a preventative tumor model in nude mice indicates that targeting this peptide by the use of mAb16D10 inhibits the growth of SOJ-6 xenografts. The specificity of mAb16D10 for pancreatic tumors and the possibility to obtain recombinant structures of mucin-like peptides recognized by mAb16D10 and mAbJ28 are promising tools in immunologic approaches to cure pancreatic cancers.
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