ArticleBMC plant biology2005
The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue of a major regulator of eukaryotic cell growth.
Article in BMC plant biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Big1 is a cell-cycle regulator linking cell size to basal body number in Tetrahymena thermophila.Current biology : CB · 2026Article
- Compound Inflorescence (S) represses fruit growth and seed development in tomato.Molecular horticulture · 2026Article
- Big1 is a cell cycle regulator linking cell size to basal body number.bioRxiv : the preprint server for biology · 2025Article
- Transcriptomic Analysis of Cold-Induced Temporary Cysts in Marine DinoflagellateInternational journal of molecular sciences · 2025Article
- 40S Ribosomal protein S6 kinase integrates daylength perception and growth regulation in Arabidopsis thaliana.Plant physiology · 2024Article
- Review
- Brassinosteroids modulate autophagy through phosphorylation of RAPTOR1B by the GSK3-like kinase BIN2 in Arabidopsis.Autophagy · 2023Article
- Protuberances are organized distinct regions of long-term callus: histological and transcriptomic analyses in kiwifruit.Plant cell reports · 2021Article
- Article
- Combating stress: the interplay between hormone signaling and autophagy in plants.Journal of experimental botany · 2020Review
- Autophagy in Plant: A New Orchestrator in the Regulation of the Phytohormones Homeostasis.International journal of molecular sciences · 2019Review
- Article
- Inhibition of TOR Represses Nutrient Consumption, Which Improves Greening after Extended Periods of Etiolation.Plant physiology · 2018Article
- TORC1-Dependent Phosphorylation Targets in Fission Yeast.Biomolecules · 2017Review
- ANGUSTIFOLIA, a Plant Homolog of CtBP/BARS Localizes to Stress Granules and Regulates Their Formation.Frontiers in plant science · 2017Article
- Links between ER stress and autophagy in plants.Plant signaling & behavior · 2013Review
- Article
- Transcriptome analysis identifies novel responses and potential regulatory genes involved in seasonal dormancy transitions of leafy spurge (Euphorbia esula L.).BMC genomics · 2008Article
- Target of rapamycin and LST8 proteins associate with membranes from the endoplasmic reticulum in the unicellular green alga Chlamydomonas reinhardtii.Eukaryotic cell · 2008Article
- Stem cell signalling networks in plants.Plant molecular biology · 2006Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTOR, the target of the antibiotic rapamycin in both yeast and mammalian cells, is a potent cell growth regulator in all eukaryotes. It acts through the phosphorylation of downstream effectors that are recruited to it by the binding partner Raptor. In Arabidopsis, Raptor activity is essential for postembryonic growth. Though comparative studies suggest potential downstream effectors, no Raptor binding partners have been described in plants.
resultsAtRaptor1B, a plant Raptor homologue, binds the AML1 (Arabidopsis Mei2-like 1) protein in a yeast two-hybrid assay. This interaction is mediated by the N-terminal 219 residues of AML1, and marks AML1 as a candidate AtTOR kinase substrate in plants. The AML1 N-terminus additionally carries transcriptional activation domain activity. Plants homozygous for insertion alleles at the AML1 locus, as well as plants homozygous for insertion alleles at all five loci in the AML gene family, bolt earlier than wild-type plants.
conclusionAML1 interacts with AtRaptor1B, homologue of a protein that recruits substrates for phosphorylation by the major cell-growth regulator TOR. Identification of AML1 as a putative downstream effector of TOR gives valuable insights into the plant-specific mode of action of this critical growth regulator.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.