ArticleImmunology2005
Haemopoietic mechanisms in murine allergic upper and lower airway inflammation.
Article in Immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Pathobiology and Regulation of Eosinophils, Mast Cells, and Basophils in Allergic Asthma.Immunological reviews · 2025Review
- Association between allergic rhinitis, nasal polyps, chronic sinusitis and chronic respiratory diseases: a mendelian randomization study.BMC pulmonary medicine · 2025Article
- History of allergic rhinitis and risk of asthma; a systematic review and meta-analysis.The World Allergy Organization journal · 2019Article
- Review
- A novel microbe-based treatment that attenuates the inflammatory profile in a mouse model of allergic airway disease.Scientific reports · 2016Article
- An intratracheal challenge murine model of asthma: can bronchial inflammation affect the nose?Allergy, asthma & immunology research · 2015Article
- Local proliferation and mobilization of CCR3(+) CD34(+) eosinophil-lineage-committed cells in the lung.Immunology · 2011Article
- Allergic conjunctivitis and the impact of allergic rhinitis.Current allergy and asthma reports · 2010Review
- Obesity enhances eosinophilic inflammation in a murine model of allergic asthma.British journal of pharmacology · 2010Article
- Stem cells, inflammation and allergy.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2009Article
- Rhinosinusitis and asthma: the missing link.Current opinion in pulmonary medicine · 2009Review
- Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma.Evidence-based complementary and alternative medicine : eCAM · 2008Article
- Effects of radix adenophorae and cyclosporine A on an OVA-induced murine model of asthma by suppressing to T cells activity, eosinophilia, and bronchial hyperresponsiveness.Mediators of inflammation · 2008Article
- Article
- Rodent models of allergic rhinitis: relevance to human pathophysiology.Current allergy and asthma reports · 2007Review
- Expression of Toll-like receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis.Respiratory research · 2007Article
- Systemic effects of oral tolerance on inflammation: mobilization of lymphocytes and bone marrow eosinopoiesis.Immunology · 2006Article
- Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease.Cellular immunology · 2005Article
- Relationship between allergic rhinitis and allergic conjunctivitis (allergic rhinoconjunctivitis) - review.Romanian journal of ophthalmologyReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eosinophil recruitment to the airways, including involvement of haemopoietic eosinophil-basophil progenitors (Eo/B-CFU), is primarily regulated by interleukin-5 (IL-5) and eotaxin. In this study, we investigated the haemopoietic mechanisms in upper and lower airway eosinophilic inflammation. Ovalbumin (OVA) sensitized and challenged BALB/c mice were used to establish isolated upper (UAC), isolated lower (LAC), or combined upper and lower airway (ULAC) inflammation. Airway, blood and bone marrow responses were evaluated in each model. Numbers of airway eosinophils and CD4(+) cells were increased significantly in the nasal mucosa in UAC and ULAC mice, and in the lung tissue in LAC and ULAC groups. Levels of IL-5 and eotaxin were increased significantly in the nasal lavage fluid (NL) in UAC and ULAC mice, and in the bronchoalveolar lavage fluid (BAL) in LAC and ULAC groups. The proportion of IL-5-responsive bone marrow Eo/B-CFU was significantly higher than the control in all treatment groups, but peaked much earlier in the ULAC group. Kinetic studies revealed that IL-5 and eotaxin in NL, BAL and serum peaked between 2 and 12 hr after OVA challenge in ULAC mice, and at 24 hr in UAC mice, related to the timing of maximal progenitor responses. These data support the concept that the systemic mechanisms linking rhinitis to asthma depend on the location and extent of airway allergen exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.