ReviewPediatric nephrology (Berlin, Germany)2005
A mechanistic approach to inherited polycystic kidney disease.
Review in Pediatric nephrology (Berlin, Germany), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- A TRPM4-dependent current in murine renal primary cilia.American journal of physiology. Renal physiology · 2015Article
- Electrical Signaling in Motile and Primary Cilia.Bioscience · 2014Article
- Inversin modulates the cortical actin network during mitosis.American journal of physiology. Cell physiology · 2013Article
- Polycystins, focal adhesions and extracellular matrix interactions.Biochimica et biophysica acta · 2011Review
- Renal cystic diseases in children: new concepts.Pediatric radiology · 2010Review
- Defects in ciliary localization of Nek8 is associated with cystogenesis.Pediatric nephrology (Berlin, Germany) · 2008Article
- The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation.Disease models & mechanismsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
There are approximately six and a half million people, of the estimated world population of six billion, with inherited polycystic kidney disease. Polycystic kidney diseases have a broad spectrum of associated findings that distinguish and define them as specific disease states. The dysregulation of renal tubular epithelial cell biology, including cell polarity, cell signaling, proliferation and apoptosis, basement membrane and matrix abnormalities, and fluid transport, has been postulated to contribute to cystogenesis. Evidence is currently accumulating that supports an association of the primary cilium and basal body, as well as the focal adhesion assembly, with polycystic kidney diseases. Renal cystogenesis may be the result of a disruption of a critical feedback loop that regulates tissue morphology based on the epithelial cell environment.
Indexed as
Identifiers
15719257What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.