ArticleEuropean journal of nutrition2005
Increased immune response in mice consuming rice bran oil.
Article in European journal of nutrition, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 81 citations in OpenAlex.
- Added γ-oryzanol boosted anti-inflammatory effects of canola oil in adult subjects with type 2 diabetes: a randomized controlled clinical trial.European journal of nutrition · 2024Trial
- Effects of Chronic Administration of a Standardized Rice Bran Supplement on Sleep Architecture and Profiles in Mice: A Comparative Study with a Hypnotic Drug Zolpidem.Journal of microbiology and biotechnology · 2025Article
- Contemporary Views of the Extraction, Health Benefits, and Industrial Integration of Rice Bran Oil: A Prominent Ingredient for Holistic Human Health.Foods (Basel, Switzerland) · 2024Review
- Immune-Enhancing Effect of Submerged Culture ofInternational journal of molecular sciences · 2022Article
- Growth Performance, Antioxidant Activity, Immune Status, Meat Quality, Liver Fat Content, and Liver Histomorphology of Broiler Chickens Fed Rice Bran Oil.Animals : an open access journal from MDPI · 2021Article
- Pediococcus Pentosaceus from the Sweet Potato Fermented Ger-Minated Brown Rice Can Inhibit Type I Hypersensitivity in RBL-2H3 Cell and BALB/c Mice Models.Microorganisms · 2021Article
- Advances on the Valorisation and Functionalization of By-Products and Wastes from Cereal-Based Processing Industry.Foods (Basel, Switzerland) · 2020Review
- Rice bran oil ameliorates inflammatory responses by enhancing mitochondrial respiration in murine macrophages.PloS one · 2019Article
- Efficacy of energy supplementation on growth performance and immune response of suckling pigs.Journal of animal science · 2018Article
- Immunomodulatory Effects of Kuseonwangdogo-Based Mixed Herbal Formula Extracts on a Cyclophosphamide-Induced Immunosuppression Mouse Model.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Scientific Evidence of Rice By-Products for Cancer Prevention: Chemopreventive Properties of Waste Products from Rice Milling on CarcinogenesisBioMed research international · 2017Review
- In vitro antioxidant assay of medium chain fatty acid rich rice bran oil in comparison to native rice bran oil.Journal of food science and technology · 2015Article
- Nootropic and anti-stress effects of rice bran oil in male rats.Journal of food science and technology · 2015Article
- Dietary rice bran protects against rotavirus diarrhea and promotes Th1-type immune responses to human rotavirus vaccine in gnotobiotic pigs.Clinical and vaccine immunology : CVI · 2014Article
- Chemopreventive properties of dietary rice bran: current status and future prospects.Advances in nutrition (Bethesda, Md.) · 2012Review
- Consumption of rice bran increases mucosal immunoglobulin A concentrations and numbers of intestinal Lactobacillus spp.Journal of medicinal food · 2012Article
- Metabolomic and functional genomic analyses reveal varietal differences in bioactive compounds of cooked rice.PloS one · 2010Article
- Article
- Diet supplementation for 5 weeks with polyphenol-rich cereals improves several functions and the redox state of mouse leucocytes.European journal of nutrition · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolyunsaturated fatty acids play a key role in a number of biological functions. Rice bran oil (RBO) is rich in linoleic acid, an essential n-6 fatty acid. n-6 fatty acids are said to have proinflammatory effects as a result of an increase in n-6 fatty acid-derived eicosanoids. RBO is also rich in gamma-oryzanol, a compound from the unsaponifiable fraction, with antioxidant properties.
objectiveThe aim of this work is to examine the effect of RBO-and/or gamma-oryzanol-enriched diets on the regulation of the immune response.
methods4 week-old Balb/C mice were fed diets enriched with either RBO or high oleic-sunflower oil (HOSO), for one month. Serum samples, bone marrow-derived macrophages and lymphocytes from the spleen were collected.
resultsCompared to HOSO, our results show that RBO modulates the immune system by enhancing B-lymphocyte proliferation (6842 +/- 2959 vs 10073 +/- 4186 cpm; HOSO vs RBO; n = 10 per group) and TH1-type cytokines such as IL-2 (55.85 +/- 18.2 vs 101.7 +/- 21.6 pg/ml) or TNF-alpha (49.12 +/- 18.6 vs 184.9 +/- 46.2 pg/ml; HOSO vs RBO) in a significant way (n = 10 per group). Moreover, the reduction found in the TH2 cytokine IL-4 (7.59 +/- 2.3 vs 4.48 +/- 1.6 pg/ml) and IgE (56.9 +/- 39.2 vs 42.4 +/- 35.2 ng/ ml; HOSO vs RBO, n = 10 per group) levels suggests RBO may have antiallergenic properties. To elucidate the role of gamma-oryzanol, a similar study was also carried out including diets enriched with refined RBO or HOSO containing gamma-oryzanol (2 %). Our results suggest that although gamma-oryzanol may modulate the immune system, it is not responsible for the overall immunostimulation effect seen for RBO.
conclusionsRBO-enriched diets could be useful in situations where a potentiation of the immune response was required. The fatty acids composition, more than the unsaponifiable fraction, might be responsible for this effect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.