ArticleIntensive care medicine2005
High interleukin 12 and low interleukin 10 production after in vitro stimulation detected in sepsis survivors.
Article in Intensive care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Genetic associations between autoimmune diseases and the risks of severe sepsis and 28-day mortality: a two-sample Mendelian randomization study.Frontiers in medicine · 2024Article
- Evaluation of Biomarkers from Peritoneal Fluid as Predictors of Severity for Abdominal Sepsis Patients Following Emergency Laparotomy.Journal of inflammation research · 2023Article
- Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options.Military Medical Research · 2022Review
- Impact of history of mental disorders on short-term mortality among hospitalized patients with sepsis: A population-based cohort study.PloS one · 2022Article
- PMMA-Based Continuous Hemofiltration Modulated Complement Activation and Renal Dysfunction in LPS-Induced Acute Kidney Injury.Frontiers in immunology · 2021Article
- Risk alleles for tuberculosis infection associate with reduced immune reactivity in a wild mammalian host.Proceedings. Biological sciences · 2019Article
- The association between autoimmune disease and 30-day mortality among sepsis ICU patients: a cohort study.Critical care (London, England) · 2019Article
- Differential Immune Phenotypes in Human Monocytes Induced by Non-Host-Adapted Salmonella enterica Serovar Choleraesuis and Host-AdaptedInfection and immunity · 2018Article
- Hyporesponsiveness of natural killer cells and impaired inflammatory responses in critically ill patients.BMC immunology · 2017Article
- Low-Dose Steroid Therapy Is Associated with Decreased IL-12 Production in PBMCs of Severe Septic Patients.Mediators of inflammation · 2016Article
- Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding.Physiological reviews · 2013Article
- Cytokines in sepsis: potent immunoregulators and potential therapeutic targets--an updated view.Mediators of inflammation · 2013Review
- Serial increase of IL-12 response and human leukocyte antigen-DR expression in severe sepsis survivors.Critical care (London, England) · 2011Article
- Functional relevance of IL-10 promoter polymorphisms for sepsis development.Critical care (London, England) · 2010Article
- "Host tissue damage" signal ATP impairs IL-12 and IFNgamma secretion in LPS stimulated whole human blood.Intensive care medicine · 2008Article
- Ficoll-separated mononuclear cells from sepsis patients are contaminated with granulocytes.Intensive care medicine · 2008Article
- Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma.Blood · 2008Article
- Evaluation of serum C-reactive protein, procalcitonin, tumor necrosis factor alpha, and interleukin-10 levels as diagnostic and prognostic parameters in patients with community-acquired sepsis, severe sepsis, and septic shock.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2006Article
- Interleukin-10-1082 promoter polymorphism in association with cytokine production and sepsis susceptibility.Intensive care medicine · 2006Article
- Soluble triggering receptor expressed on myeloid cells 1 as an anti-inflammatory mediator in sepsis.Intensive care medicine · 2006Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate viability of isolated peripheral blood mononuclear cells (PBMC) and production of cytokines in vitro after stimulation as prognostic factors for survival in sepsis patients.
designProspective study of the biological response of PBMC in the onset of severe sepsis.
settingResearch laboratory of molecular biology and immunology and university hospital ICU, Faculty of Medicine, Trakia University. PATIENTS: Twenty-three patients meeting the criteria for severe sepsis, and 14 control subjects.
interventionsIsolated PBMC were stimulated in vitro with: C3-binding glycoprotein (C3bgp; 30 microg), lipopolysaccharide (30 microg), phytohemagglutinin (20 microg), pokeweed mitogen (30 microg), and dexamethasone (500 microg). MEASUREMENTS AND
resultsWe measured the levels of interleukins (IL) 6, 10, and 12 in culture supernatants. Stimulation with C3bgp and phytohemagglutinin led to significantly lower PBMC secretion of IL-6 in nonsurvivors than in survivors and healthy donors. Stimulation with C3bgp, lipopolysaccharide, and pokeweed mitogen considerably reduced IL-12 production in nonsurvivors. Stimulation with lipopolysaccharide and pokeweed mitogen caused immune cells in nonsurvivors to produce higher levels of IL-10 than in survivors. Survival of PBMC reduced viability for nonsurvivors' PBMC, both spontaneously and as induced by lipopolysaccharide or pokeweed mitogen.
conclusionsThe viability of PBMC at the onset of sepsis and enhanced production of IL-12 and diminished production of IL-10 after stimulation with all stimuli used may be a favorable prognostic factor in sepsis.
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