ArticleNucleic acids research2005
Relative predicted protein levels of functionally associated proteins are conserved across organisms.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Dicodon-based measures for modeling gene expression.Bioinformatics (Oxford, England) · 2023Article
- Article
- Analysis of chromosomes and nucleotides in rice to predict gene expression through codon usage pattern.Saudi journal of biological sciences · 2021Article
- Prediction of gene expression under drought stress in spring wheat using codon usage pattern.Saudi journal of biological sciences · 2021Article
- A scheme for inferring viral-host associations based on codon usage patterns identifies the most affected signaling pathways during COVID-19.Journal of biomedical informatics · 2021Article
- Effect of genome composition and codon bias on infectious bronchitis virus evolution and adaptation to target tissues.BMC genomics · 2021Article
- Gene expression of functionally-related genes coevolves across fungal species: detecting coevolution of gene expression using phylogenetic comparative methods.BMC genomics · 2020Article
- Analysis of codon usage patterns and influencing factors in Nipah virus.Virus research · 2019Article
- Comparative expression profiling reveals widespread coordinated evolution of gene expression across eukaryotes.Nature communications · 2018Article
- Gaining insights into the codon usage patterns of TP53 gene across eight mammalian species.PloS one · 2015Article
- Deconstruction of archaeal genome depict strategic consensus in core pathways coding sequence assembly.PloS one · 2015Article
- Genome-scale analysis of translation elongation with a ribosome flow model.PLoS computational biology · 2011Article
- Codon usage variability determines the correlation between proteome and transcriptome fold changes.BMC systems biology · 2011Article
- A comprehensive, quantitative, and genome-wide model of translation.PLoS computational biology · 2010Article
- Inferring modules of functionally interacting proteins using the Bond Energy Algorithm.BMC bioinformatics · 2008Article
- Sequence-based prediction of protein-protein interactions by means of codon usage.Genome biology · 2008Article
- An improved implementation of codon adaptation index.Evolutionary bioinformatics online · 2007Article
- Characterization and prediction of protein-protein interactions within and between complexes.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
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Authors and funding
2 authors.
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Abstract
We show that the predicted protein levels of functionally related proteins change in a coordinated fashion over many unicellular organisms. For each protein, we created a profile containing a protein abundance measure in each of a set of organisms. We show that for functionally related proteins these profiles tend to be correlated. Using the Codon Adaptation Index as a predictor of protein abundance in 48 unicellular organisms, we demonstrated this phenomenon for two types of functional relations: for proteins that physically interact and for proteins involved in consecutive steps within a metabolic pathway. Our results suggest that the protein abundance levels of functionally related proteins co-evolve.
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