ArticleNucleic acids research2005
Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- The cullin Rtt101 promotes ubiquitin-dependent DNA-protein crosslink repair across the cell cycle.Nucleic acids research · 2024Article
- Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The ATP-dependent chromatin remodelling enzyme Uls1 prevents Topoisomerase II poisoning.Nucleic acids research · 2019Article
- The Role of Mms22p in DNA Damage Response in Candida albicans.G3 (Bethesda, Md.) · 2015Article
- Mms1 and Mms22 stabilize the replisome during replication stress.Molecular biology of the cell · 2011Article
- A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.Molecular cell · 2010Article
- Article
- Identification of response-modulated genetic interactions by sensitivity-based epistatic analysis.BMC genomics · 2010Article
- Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing.The Journal of biological chemistry · 2010Article
- Article
- A negatively charged residue in place of histone H3K56 supports chromatin assembly factor association but not genotoxic stress resistance.DNA repair · 2009Article
- Cellular pathways for DNA repair and damage tolerance of formaldehyde-induced DNA-protein crosslinks.DNA repair · 2009Article
- The evolutionary origin of man can be traced in the layers of defunct ancestral alpha satellites flanking the active centromeres of human chromosomes.PLoS genetics · 2009Article
- Targeting DNA topoisomerase II in cancer chemotherapy.Nature reviews. Cancer · 2009Review
- Interplay of DNA repair pathways controls methylation damage toxicity in Saccharomyces cerevisiae.Genetics · 2008Article
- Chromatin-associated genes protect the yeast genome from Ty1 insertional mutagenesis.Genetics · 2008Article
- Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe.Genetics · 2007Article
- Systematic genome instability screens in yeast and their potential relevance to cancer.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Esc4/Rtt107 and the control of recombination during replication.DNA repair · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The cleavage reaction of topoisomerase II, which creates double-stranded DNA breaks, plays a central role in both the cure and initiation of cancer. Therefore, it is important to understand the cellular processes that repair topoisomerase II-generated DNA damage. Using a genome-wide approach with Saccharomyces cerevisiae, we found that Deltamre11, Deltaxrs2, Deltarad50, Deltarad51, Deltarad52, Deltarad54, Deltarad55, Deltarad57 and Deltamms22 strains were hypersensitive to etoposide, a drug that specifically increases levels of topoisomerase II-mediated DNA breaks. These results confirm that the single-strand invasion pathway of homologous recombination is the major pathway that repairs topoisomerase II-induced DNA damage in yeast and also indicate an important role for Mms22p. Although Deltamms22 strains are sensitive to several DNA-damaging agents, little is known about the function of Mms22p. Deltamms22 cultures accumulate in G2/M, and display an abnormal cell cycle response to topoisomerase II-mediated DNA damage. MMS22 appears to function outside of the single-strand invasion pathway, but levels of etoposide-induced homologous recombination in Deltamms22 cells are lower than wild-type. MMS22 is epistatic with RTT101 and RTT107, genes that encode its protein binding partners. Finally, consistent with a role in DNA processes, Mms22p localizes to discrete nuclear foci, even in the absence of etoposide or its binding partners.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.