ArticleThe Journal of physiology2005
Mechanical activation of rectal intraganglionic laminar endings in the guinea pig distal gut.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- Using tissue clearing and light sheet fluorescence microscopy for the three-dimensional analysis of sensory and sympathetic nerve endings that innervate bone and dental tissue of mice.The Journal of comparative neurology · 2024Article
- Gut feelings: mechanosensing in the gastrointestinal tract.Nature reviews. Gastroenterology & hepatology · 2022Review
- Neural signalling of gut mechanosensation in ingestive and digestive processes.Nature reviews. Neuroscience · 2022Review
- A single baroreceptor unit consists of multiple sensors.Scientific reports · 2021Article
- Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility.Nature reviews. Gastroenterology & hepatology · 2020Review
- Review
- Quantifying Patterns of Smooth Muscle Motility in the Gut and Other Organs With New Techniques of Video Spatiotemporal Mapping.Frontiers in physiology · 2018Article
- Characterization of Simultaneous Pressure Waves as Biomarkers for Colonic Motility Assessed by High-Resolution Colonic Manometry.Frontiers in physiology · 2018Article
- Electrophysiological characterization of human rectal afferents.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Mechanosensitivity in the enteric nervous system.Frontiers in cellular neuroscience · 2015Review
- Distribution across tissue layers of extrinsic nerves innervating the mouse colorectum - an in vitro anterograde tracing study.Neurogastroenterology and motility · 2014Article
- Extrinsic primary afferent signalling in the gut.Nature reviews. Gastroenterology & hepatology · 2013Review
- Imaging stretch-activated firing of spinal afferent nerve endings in mouse colon.Frontiers in neuroscience · 2013Article
- Gut feelings: the emerging biology of gut-brain communication.Nature reviews. Neuroscience · 2011Review
- Loss of visceral pain following colorectal distension in an endothelin-3 deficient mouse model of Hirschsprung's disease.The Journal of physiology · 2011Article
- Locality-dependent descending reflex motor activity in the anal canal--cholinergic and nitrergic contributions in the rat model.Acta pharmacologica Sinica · 2009Article
- Identification of medium/high-threshold extrinsic mechanosensitive afferent nerves to the gastrointestinal tract.Gastroenterology · 2009Article
- Visceral pain: the neurophysiological mechanism.Handbook of experimental pharmacology · 2009Review
- Phasic and tonic stress-strain data obtained in intact intestinal segment in vitro.Digestive diseases and sciences · 2008Article
- TNBS-induced inflammation modulates the function of one class of low-threshold rectal mechanoreceptors in the guinea pig.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rectum receives specialized extrinsic afferent innervation by stretch-sensitive, low threshold, slowly adapting mechanoreceptors, with transduction sites shown to correspond to rectal intraganglionic laminar endings (IGLEs). Rectal IGLEs are located in myenteric ganglia, surrounded by the longitudinal and circular smooth muscle layers; in this study we investigated the mechanical stimuli to which they respond. Mechanoreceptors had graded responses to highly focal transmural compression with von Frey hairs. They were activated when stretched circumferentially by imposed increases of both length and load. Under both conditions, firing typically occurred in bursts associated with phasic muscle contractions. However, many contractions did not evoke firing. Longitudinal stretch also evoked firing, again associated with contractile activity. Thus, mechanoreceptors did not show directional sensitivity. Two agonists that excited smooth muscle directly (0.1 microm [beta-Ala(8)]-neurokinin A (4-10) and 1 microm carbachol) activated rectal mechanoreceptors, but not in the presence of Ca(2)(+)-free solution or when preparations were kept entirely slack. We measured the dimensions, in both longitudinal and circumferential axes, of receptive fields during smooth muscle contractile activity, using video micrography. Contractile activity within the receptive field often differed significantly from the behaviour of the preparation as a whole, providing an explanation for many of the discrepancies between gross contractility and firing. Simultaneous contraction of both muscle layers within the receptive field was the strongest predictor of mechanoreceptor activation. Our results suggest that rectal mechanoreceptors do not act simply as tension receptors: rather they appear to detect mechanical deformation of myenteric ganglia - especially flattening - associated with stretch of the receptive field, or contractions of smooth muscle within the receptive field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.