ArticleBMC cancer2005
Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus.
Article in BMC cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- The pivotal role of irradiation-induced apoptosis in the pathogenesis and therapy of medulloblastoma.Cancer reports (Hoboken, N.J.) · 2024Review
- Regulation of Chemosensitivity in Human Medulloblastoma Cells by p53 and the PI3 Kinase Signaling Pathway.Molecular cancer research : MCR · 2022Article
- TORC1/2 kinase inhibition depletes glutathione and synergizes with carboplatin to suppress the growth of MYC-driven medulloblastoma.Cancer letters · 2021Article
- Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation.Disease models & mechanisms · 2018Article
- Endogenous Retrovirus 3 - History, Physiology, and Pathology.Frontiers in microbiology · 2017Review
- DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Article
- Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53.Cancer research · 2015Article
- Gender effect in experimental models of human medulloblastoma: does the estrogen receptor β signaling play a role?PloS one · 2014Article
- Definition of genetic events directing the development of distinct types of brain tumors from postnatal neural stem/progenitor cells.Cancer research · 2012Article
- An animal model of MYC-driven medulloblastoma.Cancer cell · 2012Article
- p53 expression predicts dismal outcome for medulloblastoma patients with metastatic disease.Journal of neuro-oncology · 2012Article
- p16INK4A and p14ARF tumor suppressor pathways are deregulated in malignant rhabdoid tumors.Journal of neuropathology and experimental neurology · 2011Article
- Medulloblastoma comprises four distinct molecular variants.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2011Article
- Molecular diagnostics in embryonal brain tumors.Brain pathology (Zurich, Switzerland) · 2011Review
- Medulloblastoma in children: a 32-year experience from a single institution.Journal of neuro-oncology · 2008Article
- c-Myc and beta-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal tumor family in mice.Oncogene · 2008Article
- PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo.Genes & development · 2008Article
- Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D.Journal of neuro-oncology · 2008Article
- Overexpressed TP73 induces apoptosis in medulloblastoma.BMC cancer · 2007Article
- Review: In vivo models for defining molecular subtypes of the primitive neuroectodermal tumor genome: current challenges and solutions.In vivo (Athens, Greece)Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundp53 mutations are relatively uncommon in medulloblastoma, but abnormalities in this cell cycle pathway have been associated with anaplasia and worse clinical outcomes. We correlated p53 protein expression with pathological subtype and clinical outcome in 75 embryonal brain tumors. The presence of JC virus, which results in p53 protein accumulation, was also examined.
methodsp53 protein levels were evaluated semi-quantitatively in 64 medulloblastomas, 3 atypical teratoid rhabdoid tumors (ATRT), and 8 supratentorial primitive neuroectodermal tumors (sPNET) using immunohistochemistry. JC viral sequences were analyzed in DNA extracted from 33 frozen medulloblastoma and PNET samples using quantitative polymerase chain reaction.
resultsp53 expression was detected in 18% of non-anaplastic medulloblastomas, 45% of anaplastic medulloblastomas, 67% of ATRT, and 88% of sPNET. The increased p53 immunoreactivity in anaplastic medulloblastoma, ATRT, and sPNET was statistically significant. Log rank analysis of clinical outcome revealed significantly shorter survival in patients with p53 immunopositive embryonal tumors. No JC virus was identified in the embryonal brain tumor samples, while an endogenous human retrovirus (ERV-3) was readily detected.
conclusionImmunoreactivity for p53 protein is more common in anaplastic medulloblastomas, ATRT and sPNET than in non-anaplastic tumors, and is associated with worse clinical outcomes. However, JC virus infection is not responsible for increased levels of p53 protein.
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