Evidence map›Paper›PMID 15717662›Full record

ReviewJournal of endocrinological investigation2004

The overtraining syndrome in athletes: a stress-related disorder.

A Angeli, M Minetto, A Dovio, P Paccotti

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of endocrinological investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 165 citations in OpenAlex.

  1. The Impact of Sports Involvement on Body Image Perception and Ideals: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023
    Pooled it
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  15. Observational
  16. Monitoring Psychometric States of Recovery to Improve Performance in Soccer Players: A Brief Review.International journal of environmental research and public health · 2022
    Review
  17. Associations between Training Load and Well-Being in Elite Beach Soccer Players: A Case Report.International journal of environmental research and public health · 2022
    Article
  18. Article
  19. Article
  20. Physiological and Psychological Responses to a Maximal Swimming Exercise Test in Adolescent Elite Athletes.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

A AngeliGeneral Medical Clinic, Departement of Clinical and Biological Sciences, San Luigi Hospital, Orbassano, Turin, Italy.
M Minetto
A Dovio
P Paccotti
Ospedale San Luigi Gonzaga · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical exercise is a type of allostatic load for several endocrine systems, notably the hypothalamic-pituitary-adrenal (HPA) axis. Athletes undergoing a strenuous training schedule can develop a significant decrease in performance associated with systemic symptoms or signs: the overtraining syndrome (OTS). This is a stress-related condition that consists of alteration of physiological functions and adaptation to performance, impairment of psychological processing, immunological dysfunction and biochemical abnormalities. Universally agreed diagnostic criteria for OTS are lacking. The pituitary-adrenal response to a standardized exercise test is usually reduced in overtrained athletes. This HPA dysfunction could reflect the exhaustion stage of Selye's general adaptation syndrome. The most attractive hypothesis that accounts for the observed neuro-endocrine-immune dysregulation is the Smith's cytokine hypothesis of OTS. It assumes that physical training can produce muscle and skeletal trauma, thus generating a local inflammatory reaction. With the excessive repetition of the training stimulus the local inflammation can generate a systemic inflammatory response. The main actors of these processes are the cytokines, polypeptides that modulate HPA function in and outside the brain at nearly every level of activity. It is hoped that future research will focus on endogenous risk factors for morbidities related to the neuro-endocrine-immune adaptation to exercise.

Indexed as

Adaptation, PhysiologicalInflammationStress, PsychologicalCytokinesFatigueHumansHypothalamo-Hypophyseal SystemPeptidesPhysical ExertionPituitary-Adrenal SystemRisk FactorsSportsSyndromeCytokinesPeptides

Identifiers

PMID15717662
OpenAlexW2073564445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.