ArticleLeukemia2005
Concurrent translocation of BCL2 and MYC with a single immunoglobulin locus in high-grade B-cell lymphomas.
Article in Leukemia, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Selective MYC 5' amplification in postirradiation/lymphedema-associated angiosarcoma.Virchows Archiv : an international journal of pathology · 2026Article
- Article
- MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit follicular lymphomas associated with t(8;14;18)(q24;q32;q21).Journal of clinical and experimental hematopathology : JCEH · 2022Article
- Co-Operativity between MYC and BCL-2 Pro-Survival Proteins in Cancer.International journal of molecular sciences · 2021Review
- Targeting MYC in multiple myeloma.Leukemia · 2018Review
- Review
- FBXO10 deficiency and BTK activation upregulate BCL2 expression in mantle cell lymphoma.Oncogene · 2016Article
- MYC and the control of apoptosis.Cold Spring Harbor perspectives in medicine · 2014Review
- Characterization of a case of follicular lymphoma transformed into B-lymphoblastic leukemia.Molecular cytogenetics · 2013Article
- Atypical Burkitt's lymphoma transforming from follicular lymphoma.Diagnostic pathology · 2011Review
- Clinicopathological features of lymphoma/leukemia patients carrying both BCL2 and MYC translocations.Haematologica · 2009Article
- Establishment of CD5 and CD10 double-positive mature B-cell line, WILL1, showing complex 8q24 translocation involving 14q32 and 6q27.International journal of hematology · 2008Article
- Thirty patients with primary plasma cell leukemia: a single center experience.Medical oncology (Northwood, London, England) · 2008Article
- t(8;14;18): a 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia.Molecular cancer · 2007Review
- Treatment of Burkitt lymphoma in children and adults: Lessons from Africa.Current hematologic malignancy reports · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
B-cell leukaemia or lymphoma with a combination of t(8;14)(q24;q32) of Burkitt leukaemia/lymphoma and t(14;18)(q32;q21) of follicular lymphoma may present clinically as de novo acute lymphoblastic leukaemia or transformation of follicular lymphoma to aggressive histology diffuse lymphoma. A number of cell lines have been reported with a complex t(8;14;18) with fusion of MYC, IGH and BCL2 on the same derivative 8 chromosome. The objective of this study was to determine the frequency and chromosomal features of this der(8)t(8;14;18) in a series of acute leukaemias and malignant lymphomas. A database of 1350 leukaemia and lymphoma karyotypes was searched for cases with structural alterations affecting both 8q24 and 18q21. A total of 55 cases were identified, of which eight revealed a complex der(8)t(8;14;18) with an MYC-IGH-BCL2 rearrangement resulting from translocation of BCL2 and MYC with a single disrupted IGH allele. Molecular cytogenetic investigation is essential to identify cases of high-grade leukaemia/lymphoma with concurrent translocations affecting the BCL2 and MYC loci.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.