ArticleGenetics2005
Elevated polymorphism and divergence in the class C scavenger receptors of Drosophila melanogaster and D. simulans.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 62 citations in OpenAlex.
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- Signatures of Adaptation, Constraints, and Potential Redundancy in the Canonical Immune Genes of a Key Pollinator.Genome biology and evolution · 2023Article
- Sensing microbial infections in the Drosophila melanogaster genetic model organism.Immunogenetics · 2022Review
- Population genetic analysis of autophagy and phagocytosis genes in Drosophila melanogaster and D. simulans.PloS one · 2018Article
- Detection of Regional Variation in Selection Intensity within Protein-Coding Genes Using DNA Sequence Polymorphism and Divergence.Molecular biology and evolution · 2017Article
- Perspectives on the evolutionary ecology of arthropod antimicrobial peptides.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Rapid divergence and diversification of mammalian duplicate gene functions.BMC evolutionary biology · 2015Article
- Population genetic tools for dissecting innate immunity in humans.Nature reviews. Immunology · 2013Review
- Proteus mirabilis interkingdom swarming signals attract blow flies.The ISME journal · 2012Article
- Patterns of selection and polymorphism of innate immunity genes in bumblebees (Hymenoptera: Apidae).Genetica · 2012Article
- Immune genes undergo more adaptive evolution than non-immune system genes in Daphnia pulex.BMC evolutionary biology · 2012Article
- Widespread polymorphism in the positions of stop codons in Drosophila melanogaster.Genome biology and evolution · 2012Article
- A strong deletion bias in nonallelic gene conversion.PLoS genetics · 2012Article
- Exceptional diversity, maintenance of polymorphism, and recent directional selection on the APL1 malaria resistance genes of Anopheles gambiae.PLoS biology · 2011Article
- Functional regulatory divergence of the innate immune system in interspecific Drosophila hybrids.Molecular biology and evolution · 2010Article
- Haplotype structure and expression divergence at the Drosophila cellular immune gene eater.Molecular biology and evolution · 2010Article
- Immunity and other defenses in pea aphids, Acyrthosiphon pisum.Genome biology · 2010Article
- Natural selection and genital variation: a role for the environment, parasites and sperm ageing?Genetica · 2010Article
- Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Scavenger receptor proteins are involved in the cellular internalization of a broad variety of foreign material, including pathogenic bacteria during phagocytosis. I find here that nonsynonymous divergence in three class C scavenger receptors (Sr-C's) between Drosophila melanogaster and D. simulans and between each of these species and D. yakuba is approximately four times the typical genome average. These genes also exhibit unusually high levels of segregating nonsynonymous polymorphism in D. melanogaster and D. simulans populations. A fourth Sr-C is comparatively conserved. McDonald-Kreitman tests reveal a significant excess of replacement fixations between D. melanogaster and D. simulans in the Sr-C's, but tests of polymorphic site frequency spectra do not support models of directional selection. It is possible that the molecular functions of SR-C proteins are sufficiently robust to allow exceptionally high amino acid substitution rates without compromising organismal fitness. Alternatively, SR-Cs may evolve under diversifying selection, perhaps as a result of pressure from pathogens. Interestingly, Sr-CIII and Sr-CIV are polymorphic for premature stop codons. Sr-CIV is also polymorphic for an in-frame 101-codon deletion and for the absence of one intron.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.