ArticleGenetics2005
Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegans.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 67 citations in OpenAlex.
- Analysis of genome instability and implications for the consequent phenotype inMicrobial genomics · 2023Article
- Oogenesis in Caenorhabditis elegans.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2023Review
- Article
- Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy.Clinical science (London, England : 1979) · 2022Article
- DNA repair, recombination, and damage signaling.Genetics · 2022Review
- Specificity of the DNA Mismatch Repair System (MMR) and Mutagenesis Bias in Bacteria.Molecular biology and evolution · 2018Article
- Mutational signatures of DNA mismatch repair deficiency inGenome research · 2018Article
- Evolution of the Insertion-Deletion Mutation Rate Across the Tree of Life.G3 (Bethesda, Md.) · 2016Article
- Asymmetric Context-Dependent Mutation Patterns Revealed through Mutation-Accumulation Experiments.Molecular biology and evolution · 2015Article
- Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress.PLoS neglected tropical diseases · 2015Article
- Having a direct look: analysis of DNA damage and repair mechanisms by next generation sequencing.Experimental cell research · 2014Review
- Article
- Mutation rates, spectra, and genome-wide distribution of spontaneous mutations in mismatch repair deficient yeast.G3 (Bethesda, Md.) · 2013Article
- A systems approach defining constraints of the genome architecture on lineage selection and evolvability during somatic cancer evolution.Biology open · 2013Article
- Evolution of a higher intracellular oxidizing environment in Caenorhabditis elegans under relaxed selection.PloS one · 2013Article
- DNA MMR systems, microsatellite instability and antioxidant activity variations in two species of wild bats: Myotis velifer and Desmodus rotundus, as possible factors associated with longevity.Age (Dordrecht, Netherlands) · 2012Article
- Mutation hot spots in yeast caused by long-range clustering of homopolymeric sequences.Cell reports · 2012Article
- Identification of intermediate-size non-coding RNAs involved in the UV-induced DNA damage response in C. elegans.PloS one · 2012Article
- No evidence of elevated germline mutation accumulation under oxidative stress in Caenorhabditis elegans.Genetics · 2011Article
- Simple sequence repeat variation in the Daphnia pulex genome.BMC genomics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Although it is clear that postreplicative DNA mismatch repair (MMR) plays a critical role in maintaining genomic stability in nearly all forms of life surveyed, much remains to be understood about the genome-wide impact of MMR on spontaneous mutation processes and the extent to which MMR-deficient mutation patterns vary among species. We analyzed spontaneous mutation processes across multiple genomic regions using two sets of mismatch repair-deficient (msh-2 and msh-6) Caenorhabditis elegans mutation-accumulation (MA) lines and compared our observations to mutation spectra in a set of wild-type (WT), repair-proficient C. elegans MA lines. Across most sequences surveyed in the MMR-deficient MA lines, mutation rates were approximately 100-fold higher than rates in the WT MA lines, although homopolymeric nucleotide-run (HP) loci composed of A:T base pairs mutated at an approximately 500-fold greater rate. In contrast to yeast and humans where mutation spectra vary substantially with respect to different specific MMR-deficient genotypes, mutation rates and patterns were overall highly similar between the msh-2 and msh-6 C. elegans MA lines. This, along with the apparent absence of a Saccharomyces cerevisiae MSH3 ortholog in the C. elegans genome, suggests that C. elegans MMR surveillance is carried out by a single Msh-2/Msh-6 heterodimer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.