ArticleJournal of bacteriology2005
Activation of the vrg6 promoter of Bordetella pertussis by RisA.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Architecture and regulatory functions of c-di-GMP signaling in classical Bordetella species.FEMS microbiology reviews · 2026Review
- Combined transcriptomic and ChIPseq analyses of themSystems · 2024Article
- The contribution of BvgR, RisA, and RisS to global gene regulation, intracellular cyclic-di-GMP levels, motility, and biofilm formation inFrontiers in microbiology · 2024Article
- Deep longitudinal multi-omics analysis ofFrontiers in microbiology · 2023Article
- Interference of flagellar rotation up-regulates the expression of small RNA contributing toScience advances · 2022Article
- Transcriptional profiling of human macrophages during infection withRNA biology · 2020Article
- Integrated Signaling Pathways Mediate Bordetella Immunomodulation, Persistence, and Transmission.Trends in microbiology · 2019Review
- Signal transduction-dependent small regulatory RNA is involved in glutamate metabolism of the human pathogenRNA (New York, N.Y.) · 2018Article
- A Novel Bvg-Repressed Promoter CausesJournal of bacteriology · 2018Article
- Activation of Bvg-Repressed Genes in Bordetella pertussis by RisA Requires Cross Talk from Noncooperonic Histidine Kinase RisK.Journal of bacteriology · 2017Article
- The multifaceted RisA regulon of Bordetella pertussis.Scientific reports · 2016Article
- An improved recombination-based in vivo expression technology-like reporter system reveals differential cyaA gene activation in Bordetella species.Infection and immunity · 2013Article
- BpsR modulates Bordetella biofilm formation by negatively regulating the expression of the Bps polysaccharide.Journal of bacteriology · 2012Article
- A novel sensor kinase is required for Bordetella bronchiseptica to colonize the lower respiratory tract.Infection and immunity · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The BvgAS two-component system positively regulates the expression of the virulence genes of Bordetella pertussis and negatively regulates a second set of genes whose function is unknown. The BvgAS-mediated regulation of the bvg-repressed genes is accomplished through the activation of expression of the negative regulator, BvgR. A second two-component regulatory system, RisAS, is required for expression of the bvg-repressed surface antigens VraA and VraB. We examined the roles of BvgR and RisA in the regulation of four bvg-repressed genes in B. pertussis. Our analyses demonstrated that all four genes are repressed by the product of the bvgR locus and are activated by the product of the risA locus. Deletion analysis of the vrg6 promoter identified the upstream and downstream boundaries of the promoter and, in contrast to previously published results, demonstrated that sequences downstream of the start of transcription are not required for the regulation of expression of vrg6. Gel mobility-shift experiments demonstrated sequence-specific binding of RisA to the vrg6 and vrg18 promoters, and led to the identification of two putative RisA binding sites. Finally, transcriptional analysis and Western blot analysis demonstrated that BvgR regulates neither the expression nor the stability of RisA.
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