ArticleJournal of bacteriology2005
Fis regulates transcriptional induction of RpoS in Salmonella enterica.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Perturbing H-NS function reveals roles in restricting virulence heterogeneity and pathogen adaptation.PLoS pathogens · 2026Article
- The Power Duo: How the Interplay Between Nucleoid-Associated Proteins and Small Noncoding RNAs Orchestrates the Cellular Regulatory Symphony.Molecular microbiology · 2025Review
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- Composition of Transcription Machinery and Its Crosstalk with Nucleoid-Associated Proteins and Global Transcription Factors.Biomolecules · 2021Review
- TusA Is a Versatile Protein That Links Translation Efficiency to Cell Division in Escherichia coli.Journal of bacteriology · 2021Article
- Ethanol Adaptation Strategies in Salmonella enterica Serovar Enteritidis Revealed by Global Proteomic and Mutagenic Analyses.Applied and environmental microbiology · 2019Article
- Positive Effect of Carbon Sources on Natural Transformation in Escherichia coli: Role of Low-Level Cyclic AMP (cAMP)-cAMP Receptor Protein in the Derepression of rpoS.Journal of bacteriology · 2015Article
- RpoS integrates CRP, Fis, and PhoP signaling pathways to control Salmonella Typhi hlyE expression.BMC microbiology · 2014Article
- Gene order and chromosome dynamics coordinate spatiotemporal gene expression during the bacterial growth cycle.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Regulation of the vapBC-1 toxin-antitoxin locus in nontypeable Haemophilus influenzae.PloS one · 2012Article
- Altered regulation of the OmpF porin by Fis in Escherichia coli during an evolution experiment and between B and K-12 strains.Journal of bacteriology · 2011Article
- The RpoS-mediated general stress response in Escherichia coli.Annual review of microbiology · 2011Review
- Transcriptome analysis of genes controlled by luxS/autoinducer-2 in Salmonella enterica serovar Typhimurium.Foodborne pathogens and disease · 2010Article
- Bacterial nucleoid-associated proteins, nucleoid structure and gene expression.Nature reviews. Microbiology · 2010Review
- The NlpD lipoprotein is a novel Yersinia pestis virulence factor essential for the development of plague.PloS one · 2009Article
- Vibrio vulnificus rpoS expression is repressed by direct binding of cAMP-cAMP receptor protein complex to its two promoter regions.The Journal of biological chemistry · 2008Article
- The sigmaS subunit of RNA polymerase as a signal integrator and network master regulator in the general stress response in Escherichia coli.Science progress · 2007Review
- Limited role for the DsrA and RprA regulatory RNAs in rpoS regulation in Salmonella enterica.Journal of bacteriology · 2006Article
- Bacterial stationary-state mutagenesis and Mammalian tumorigenesis as stress-induced cellular adaptations and the role of epigenetics.Current genomics · 2006Article
- Stationary-phase regulation of RpoS translation in Escherichia coli.Journal of bacteriology · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The sigma factor RpoS is known to regulate at least 60 genes in response to environmental sources of stress or during growth to stationary phase (SP). Accumulation of RpoS relies on integration of multiple genetic controls, including regulation at the levels of transcription, translation, protein stability, and protein activity. Growth to SP in rich medium results in a 30-fold induction of RpoS, although the mechanism of this regulation is not understood. We characterized the activity of promoters serving rpoS in Salmonella enterica serovar Typhimurium and report that regulation of transcription during growth into SP depends on Fis, a DNA-binding protein whose abundance is high during exponential growth and very low in SP. A fis mutant of S. enterica serovar Typhimurium showed a ninefold increase in expression from the major rpoS promoter (PrpoS) during exponential growth, whereas expression during SP was unaffected. Increased transcription from PrpoS in the absence of Fis eliminated the transcriptional induction as cells enter SP. The mutant phenotype can be complemented by wild-type fis carried on a single-copy plasmid. Fis regulation of rpoS requires the presence of a Fis site positioned at -50 with respect to PrpoS, and this site is bound by Fis in vitro. A model is presented in which Fis binding to this site allows repression of rpoS specifically during exponential growth, thus mediating transcriptional regulation of rpoS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.