ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Sodium channels in transient retinal bipolar cells enhance visual responses in ganglion cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 63 citations in OpenAlex.
- Dopamine D1 and D4 receptors contribute to light adaptation in ON-sustained retinal ganglion cells.Journal of neurophysiology · 2021Article
- Molecular and Cellular Mechanisms Underlying Somatostatin-Based Signaling in Two Model Neural Networks, the Retina and the Hippocampus.International journal of molecular sciences · 2019Review
- Diverse inhibitory and excitatory mechanisms shape temporal tuning in transient OFF α ganglion cells in the rabbit retina.The Journal of physiology · 2018Article
- Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA Is Conveyed through Wide-Field Amacrine Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Functional and Morphological Analysis of OFF Bipolar Cells.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Differential effect of brief electrical stimulation on voltage-gated potassium channels.Journal of neurophysiology · 2017Article
- Time course of EPSCs in ON-type starburst amacrine cells is independent of dendritic location.The Journal of physiology · 2016Article
- Article
- Dopamine D1 receptor expression is bipolar cell type-specific in the mouse retina.The Journal of comparative neurology · 2016Article
- Morphological and physiological analysis of type-5 and other bipolar cells in the Mouse Retina.Neuroscience · 2016Article
- Differential signalling and glutamate receptor compositions in the OFF bipolar cell types in the mouse retina.The Journal of physiology · 2016Article
- Functional Circuitry of the Retina.Annual review of vision science · 2015Article
- Calcium spike-mediated digital signaling increases glutamate output at the visual threshold of retinal bipolar cells.Journal of neurophysiology · 2015Article
- Roles of ON cone bipolar cell subtypes in temporal coding in the mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- NaV1.1 channels in axon initial segments of bipolar cells augment input to magnocellular visual pathways in the primate retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Electrical stimulation of inner retinal neurons in wild-type and retinally degenerate (rd/rd) mice.PloS one · 2013Article
- Taurine activates delayed rectifier Kv channels via a metabotropic pathway in retinal neurons.The Journal of physiology · 2013Article
- The neuronal organization of the retina.Neuron · 2012Review
- Paired-pulse plasticity in the strength and latency of light-evoked lateral inhibition to retinal bipolar cell terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- A mammalian retinal bipolar cell uses both graded changes in membrane voltage and all-or-nothing Na+ spikes to encode light.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Retinal bipolar cells are slow potential neurons that respond to photoreceptor inputs with graded potentials and do not fire action potentials. We found that transient ON bipolar cells recorded in retinal slices possess voltage-gated sodium channels located on either their dendrites or somas. The sodium currents in these neurons did not generate spikes but enhanced voltage responses evoked by visual stimulation, which selectively boosted transmission to transient ganglion cells. In contrast, sodium currents were not found in sustained ON bipolar cells, and light responses in sustained bipolar cells and ganglion cells were not affected by TTX. The presence of sodium channels in transient ON bipolar cells contributed to the separation of transient and sustained signals by selectively enhancing the responses of ON transient ganglion cells to light. Our results suggest that bipolar cell sodium channels augment transient signals and contribute to the temporal segregation of visual information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.