ArticleMolecular biology of the cell2005
Quantitative characterization of a mitotic cyclin threshold regulating exit from mitosis.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Keeping quiet: cell cycle regulator PIKMIN1 helps maintain the quiescent center.Plant physiology · 2023Article
- Regulation of intrinsic polarity establishment by a differentiation-type MAPK pathway inJournal of cell science · 2020Article
- A Clb/Cdk1-mediated regulation of Fkh2 synchronizesNPJ systems biology and applications · 2017Article
- Advances and challenges in logical modeling of cell cycle regulation: perspective for multi-scale, integrative yeast cell models.FEMS yeast research · 2017Review
- The interplay between chromosome stability and cell cycle control explored through gene-gene interaction and computational simulation.Nucleic acids research · 2016Article
- Experimental testing of a new integrated model of the budding yeast Start transition.Molecular biology of the cell · 2015Article
- Measurement and modeling of transcriptional noise in the cell cycle regulatory network.Cell cycle (Georgetown, Tex.) · 2013Article
- A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast.Molecular biology of the cell · 2013Article
- Article
- Coordination of chromatid separation and spindle elongation by antagonistic activities of mitotic and S-phase CDKs.PLoS genetics · 2013Article
- MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma.Oncogene · 2012Article
- Fragilities caused by dosage imbalance in regulation of the budding yeast cell cycle.PLoS genetics · 2010Article
- Analysis of the mitotic exit control system using locked levels of stable mitotic cyclin.Molecular systems biology · 2009Article
- Biological switches and clocks.Journal of the Royal Society, Interface · 2008Article
- A quantitative study of the division cycle of Caulobacter crescentus stalked cells.PLoS computational biology · 2008Article
- Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.Cancer cell · 2007Article
- Mathematical modeling as a tool for investigating cell cycle control networks.Methods (San Diego, Calif.) · 2007Review
- Spore germination in Saccharomyces cerevisiae: global gene expression patterns and cell cycle landmarks.Genome biology · 2007Article
- Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA.Nucleic acids research · 2007Article
- In vivo robustness analysis of cell division cycle genes in Saccharomyces cerevisiae.PLoS genetics · 2006Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Regulation of cyclin abundance is central to eukaryotic cell cycle control. Strong overexpression of mitotic cyclins is known to lock the system in mitosis, but the quantitative behavior of the control system as this threshold is approached has only been characterized in the in vitro Xenopus extract system. Here, we quantitate the threshold for mitotic block in budding yeast caused by constitutive overexpression of the mitotic cyclin Clb2. Near this threshold, the system displays marked loss of robustness, in that loss or even heterozygosity for some regulators becomes deleterious or lethal, even though complete loss of these regulators is tolerated at normal cyclin expression levels. Recently, we presented a quantitative kinetic model of the budding yeast cell cycle. Here, we use this model to generate biochemical predictions for Clb2 levels, asynchronous as well as through the cell cycle, as the Clb2 overexpression threshold is approached. The model predictions compare well with biochemical data, even though no data of this type were available during model generation. The loss of robustness of the Clb2 overexpressing system is also predicted by the model. These results provide strong confirmation of the model's predictive ability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.