ArticleDevelopment (Cambridge, England)2005
Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression.
Article in Development (Cambridge, England), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.Nature genetics · 2011Pooled it
- The Effects of Combined Exposure to Bisphenols and Perfluoroalkyls on Human Perinatal Stem Cells and the Potential Implications for Health Outcomes.International journal of molecular sciences · 2023Article
- Comprehensive Analysis of the Transcriptome-Wide mInternational journal of molecular sciences · 2023Article
- Transcriptome Analysis in High Temperature Inhibiting Spermatogonial Stem Cell Differentiation In Vitro.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor.Signal transduction and targeted therapy · 2022Article
- Characteristics of miRNAs Present in Bovine Sperm and Associations With Differences in Fertility.Frontiers in endocrinology · 2022Article
- A duplicated copy of id2b is an unusual sex-determining candidate gene on the Y chromosome of arapaima (Arapaima gigas).Scientific reports · 2021Article
- Structural and Functional Characterization of a Testicular Long Non-coding RNAFrontiers in cell and developmental biology · 2021Article
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- Ovol2, a zinc finger transcription factor, is dispensable for spermatogenesis in mice.Reproductive biology and endocrinology : RB&E · 2019Article
- Development and Genome Sequencing of a Laboratory-Inbred Miniature Pig Facilitates Study of Human Diabetic Disease.iScience · 2019Article
- Conserved role of Ovo in germline development in mouse and Drosophila.Scientific reports · 2017Article
- Expression profiles of human epididymis epithelial cells reveal the functional diversity of caput, corpus and cauda regions.Molecular human reproduction · 2016Article
- OVO-like 1 regulates progenitor cell fate in human trophoblast development.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Mammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressor.Developmental cell · 2014Article
- Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells.Developmental cell · 2014Article
- An overview of gene expression dynamics during early ovarian folliculogenesis: specificity of follicular compartments and bi-directional dialog.BMC genomics · 2013Article
- RanBPM, a scaffolding protein for gametogenesis.Current topics in developmental biology · 2013Review
- Sertoli-cell-specific knockout of connexin 43 leads to multiple alterations in testicular gene expression in prepubertal mice.Disease models & mechanisms · 2012Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies have shown that a targeted deletion of Ovol1 (previously known as movo1), encoding a member of the Ovo family of zinc-finger transcription factors, leads to germ cell degeneration and defective sperm production in adult mice. To explore the cellular and molecular mechanism of Ovol1 function, we have examined the mutant testis phenotype during the first wave of spermatogenesis in juvenile mice. Consistent with the detection of Ovol1 transcripts in pachytene spermatocytes of the meiotic prophase, Ovol1-deficient germ cells were defective in progressing through the pachytene stage. The pachytene arrest was accompanied by an inefficient exit from proliferation, increased apoptosis and an abnormal nuclear localization of the G2-M cell cycle regulator cyclin B1, but was not associated with apparent chromosomal or recombination defects. Transcriptional profiling and northern blot analysis revealed reduced expression of pachytene markers in the mutant, providing molecular evidence that pachytene differentiation was defective. In addition, the expression of Id2 (inhibitor of differentiation 2), a known regulator of spermatogenesis, was upregulated in Ovol1-deficient pachytene spermatocytes and repressed by Ovol1 in reporter assays. Taken together, our studies demonstrate a role for Ovol1 in regulating pachytene progression of male germ cells, and identify Id2 as a Ovol1 target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.