ArticleGenes & development2005
SecM facilitates translocase function of SecA by localizing its biosynthesis.
Article in Genes & development, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The ABCF proteins in Escherichia coli individually cope with 'hard-to-translate' nascent peptide sequences.Nucleic acids research · 2024Article
- Increased freedom of movement in the nascent chain results in dynamic changes in the structure of the SecM arrest motif.Bioscience reports · 2019Article
- Using the Bacterial Ribosome as a Discovery Platform for Peptide-Based Antibiotics.Biochemistry · 2019Review
- MifM-instructed translation arrest involves nascent chain interactions with the exterior as well as the interior of the ribosome.Scientific reports · 2018Article
- A photo-cross-linking approach to monitor folding and assembly of newly synthesized proteins in a living cell.The Journal of biological chemistry · 2018Article
- The Sec System: Protein Export inEcoSal Plus · 2017Review
- The ribosome and its role in protein folding: looking through a magnifying glass.Acta crystallographica. Section D, Structural biology · 2017Review
- Integrated in vivo and in vitro nascent chain profiling reveals widespread translational pausing.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Nascent chain-monitored remodeling of the Sec machinery for salinity adaptation of marine bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The translational regulatory function of SecM requires the precise timing of membrane targeting.Molecular microbiology · 2011Article
- Article
- Divergent stalling sequences sense and control cellular physiology.Biochemical and biophysical research communications · 2010Review
- Prolyl-tRNA(Pro) in the A-site of SecM-arrested ribosomes inhibits the recruitment of transfer-messenger RNA.The Journal of biological chemistry · 2006Article
- Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection.Molecular systems biology · 2006Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
"Arrest sequence" of Escherichia coli SecM interacts with the ribosomal exit tunnel and arrests its own translation elongation, which is released by cotranslational export of the nascent SecM chain. This property of SecM is essential for the basal and regulated expression of SecA. Here we report that SecM has an additional role of facilitating SecA activities. Systematic determinations of the SecA-abundance-protein export relationships of cells with different SecA contents revealed that SecA was less functional when SecM was absent from the upstream region of the secM-secA message, when SecM had the arrest-defective mutation, and also when SecM lacked the signal sequence. These results suggest that cotranslational targeting of nascent SecM to the translocon plays previously unrecognized roles of facilitating the formation of functional SecA molecules. Biosynthesis in the vicinity of the membrane and the Sec translocon will be beneficial for this multiconformation ATPase to adopt ready-to-function conformations.
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