ArticleMolecular and cellular biology2005
The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 47 citations in OpenAlex.
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- Biological importance of OCT transcription factors in reprogramming and development.Experimental & molecular medicine · 2021Review
- Permissive epigenomes endow reprogramming competence to transcriptional regulators.Nature chemical biology · 2021Article
- Reprogramming competence of OCT factors is determined by transactivation domains.Science advances · 2020Article
- Altered Translational Control of Fragile X Mental Retardation Protein on Myelin Proteins in Neuropsychiatric Disorders.Biomolecules & therapeutics · 2017Review
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- Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice.PloS one · 2016Article
- New insights on Schwann cell development.Glia · 2015Review
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- The early expansion and evolutionary dynamics of POU class genes.Molecular biology and evolution · 2014Article
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- POU-III transcription factors (Brn1, Brn2, and Oct6) influence neurogenesis, molecular identity, and migratory destination of upper-layer cells of the cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
- Octamer-binding transcription factors: genomics and functions.Frontiers in bioscience (Landmark edition) · 2013Review
- Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination.Nature neuroscience · 2010Article
- Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage.The Journal of cell biology · 2010Article
- Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation.Science (New York, N.Y.) · 2009Article
- Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For differentiation, Schwann cells rely on the class III POU domain transcription factor Oct-6, which is expressed transiently when Schwann cells have established a one-to-one relation with axons but have not yet started to myelinate. Loss of Oct-6 leads to a transient arrest in this promyelinating stage and a delay in myelination. Although the closely related POU domain protein Brn-2 is coexpressed with Oct-6 in Schwann cells, its loss has only mild consequences. Combined loss of both POU domain proteins, in contrast, dramatically increases the myelination delay, raising the question of how related POU domain proteins compare to each other in their activities. Here, we have replaced Oct-6 expression in the mouse with expression of the class III POU domain protein Brn-1. Although this protein is not normally expressed in Schwann cells, Brn-1 was capable of fully replacing Oct-6. Brn-1 efficiently induced Krox-20 expression as a prerequisite for myelination. Onset and extent of myelination were also indistinguishable from that of the wild type in mice that carried only Brn-1 instead of Oct-6 alleles. Similar to Oct-6, Brn-1 down-regulated its own expression at later stages of myelination. Thus, class III POU domain proteins can fully replace each other in Schwann cell development.
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