ArticleMolecular and cellular biology2005
Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 126 citations in OpenAlex.
- Enhancer-Mediated Formation of Nuclear Transcription Initiation Domains.International journal of molecular sciences · 2022Review
- Developmental regulation of DNA cytosine methylation at the immunoglobulin heavy chain constant locus.PLoS genetics · 2019Article
- Histone Demethylase JARID1B Is Overexpressed in Osteosarcoma and Upregulates Cyclin D1 Expression via Demethylation of H3K27me3.Oncology research · 2018Article
- Direct interaction of Ikaros and Foxp1 modulates expression of the G protein-coupled receptor G2A in B-lymphocytes and acute lymphoblastic leukemia.Oncotarget · 2016Article
- Small-molecule inhibitors of the Myc oncoprotein.Biochimica et biophysica acta · 2015Review
- Novel CTCF binding at a site in exon1A of BCL6 is associated with active histone marks and a transcriptionally active locus.Oncogene · 2015Article
- The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B.Protein & cell · 2014Article
- Uncovering enhancer functions using the α-globin locus.PLoS genetics · 2014Review
- An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation.Molecular biology of the cell · 2014Article
- Chromatin modifiers and remodellers: regulators of cellular differentiation.Nature reviews. Genetics · 2014Review
- H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction.Genome research · 2013Article
- Transcriptional environment and chromatin architecture interplay dictates globin expression patterns of heterospecific hybrids derived from undifferentiated human embryonic stem cells or from their erythroid progeny.Experimental hematology · 2013Article
- Epigenetic modifications and chromosome conformations of the beta globin locus throughout development.Stem cell reviews and reports · 2013Article
- Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- G9a histone methyltransferase activity in retinal progenitors is essential for proper differentiation and survival of mouse retinal cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Epigenetics: judge, jury and executioner of stem cell fate.Epigenetics · 2012Review
- Histone-modifying enzymes: regulators of developmental decisions and drivers of human disease.Epigenomics · 2012Review
- Epigenetic control of embryonic stem cell differentiation.Stem cell reviews and reports · 2012Review
- Understanding the molecular circuitry of cell lineage specification in the early mouse embryo.Genes · 2011Article
- Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis.Genome biology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The differentiation potential of stem cells is determined by the ability of these cells to establish and maintain developmentally regulated gene expression programs that are specific to different lineages. Although transcriptionally potentiated epigenetic states of genes have been described for haematopoietic progenitors, the developmental stage at which the formation of lineage-specific gene expression domains is initiated remains unclear. In this study, we show that an intergenic cis-acting element in the mouse lambda5-VpreB1 locus is marked by histone H3 acetylation and histone H3 lysine 4 methylation at a discrete site in embryonic stem (ES) cells. The epigenetic modifications spread from this site toward the VpreB1 and lambda5 genes at later stages of B-cell development, and a large, active chromatin domain is established in pre-B cells when the genes are fully expressed. In early B-cell progenitors, the binding of haematopoietic factor PU.1 coincides with the expansion of the marked region, and the region becomes a center for the recruitment of general transcription factors and RNA polymerase II. In pre-B cells, E2A also binds to the locus, and general transcription factors are distributed across the active domain, including the gene promoters and the intergenic region. These results suggest that localized epigenetic marking is important for establishing the transcriptional competence of the lambda5 and VpreB1 genes as early as the pluripotent ES cell stage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.