ArticleBiophysical journal2005
Directional persistence of EGF-induced cell migration is associated with stabilization of lamellipodial protrusions.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 126 citations in OpenAlex.
- Matrix metalloproteinase-9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells.FEBS open bio · 2026Article
- Ras-mediated dynamic and biphasic regulation of cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multiphoton excited polymerized biomimetic models of collagen fiber morphology to study single cell and collective migration dynamics in pancreatic cancer.Acta biomaterialia · 2024Article
- Nascent adhesions shorten the period of lamellipodium protrusion through the Brownian ratchet mechanism.Molecular biology of the cell · 2023Article
- A perspective of fluorescence microscopy for cellular structural biology with EGFR as witness.Journal of microscopy · 2023Article
- Cellular Uptake of Silica Particles Influences EGFR Signaling Pathway and is Affected in Response to EGF.International journal of nanomedicine · 2023Article
- Regulation of cell attachment, spreading, and migration by hydrogel substrates with independently tunable mesh size.Acta biomaterialia · 2022Article
- Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments.Nature communications · 2021Article
- GOLPH3 Regulates EGFR in T98G Glioblastoma Cells by Modulating Its Glycosylation and Ubiquitylation.International journal of molecular sciences · 2020Article
- RAC1-Dependent ORAI1 Translocation to the Leading Edge Supports Lamellipodia Formation and Directional Persistence.Scientific reports · 2020Article
- Combinatorial nanodot stripe assay to systematically study cell haptotaxis.Microsystems & nanoengineering · 2020Article
- Targeting non-muscle myosin II promotes corneal endothelial migration through regulating lamellipodial dynamics.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Interplay Between the Persistent Random Walk and the Contact Inhibition of Locomotion Leads to Collective Cell Behaviors.Bulletin of mathematical biology · 2019Article
- TheBiology open · 2019Article
- GMF as an Actin Network Remodeling Factor.Trends in cell biology · 2018Review
- Photo-immobilized EGF chemical gradients differentially impact breast cancer cell invasion and drug response in defined 3D hydrogels.Biomaterials · 2018Article
- Cancer Stem Cell Migration in Three-Dimensional Aligned Collagen Matrices.Current protocols in stem cell biology · 2018Article
- Anomalously diffusing and persistently migrating cells in 2D and 3D culture environments.APL bioengineering · 2018Article
- Dynamics of 3D carcinoma cell invasion into aligned collagen.Integrative biology : quantitative biosciences from nano to macro · 2018Article
- Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Migrating cells can sustain a relatively constant direction of lamellipodial protrusion and locomotion over timescales ranging from minutes to hours. However, individual waves of lamellipodial extension occur over much shorter characteristic times. Little understanding exists regarding how cells might integrate biophysical processes across these disparate timescales to control the directional persistence of locomotion. We address this issue by examining the effects of epidermal growth factor (EGF) stimulation on long-timescale directional persistence and short-timescale lamellipodial dynamics of EGF receptor-transfected Chinese hamster ovary cells migrating on fibronectin-coated substrata. Addition of EGF increased persistence, with the magnitude of increase correlating with fibronectin coating concentration. Kymographic analysis of EGF-stimulated lamellipodial dynamics revealed that the temporal stability of lamellipodial protrusions similarly increased with fibronectin concentration. A soluble RGD peptide competitor reduced both the persistence of long-timescale cell paths and the stability of short-timescale membrane protrusions, indicating that cell-substratum adhesion concomitantly influences lamellipodial dynamics and directional persistence. These results reveal the importance of adhesion strength in regulating the directional motility of cells and suggest that the short-timescale kinetics of adhesion complex formation may play a key role in modulating directional persistence over much longer timescales.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.