ArticleDigestive diseases and sciences2005
The transcriptional repressor SNAIL is overexpressed in human colon cancer.
Article in Digestive diseases and sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 104 citations in OpenAlex.
- Targeting SNAI1-Mediated Colorectal Cancer Chemoresistance and Stemness by Sphingosine Kinase 2 Inhibition.World journal of oncology · 2024Article
- O-GlcNAcylation: A Crucial Regulator in Cancer-Associated Biological Events.Cell biochemistry and biophysics · 2023Review
- Non-canonical functions of SNAIL drive context-specific cancer progression.Nature communications · 2023Article
- Tumorigenic effects of human mesenchymal stromal cells and fibroblasts on bladder cancer cells.Frontiers in oncology · 2023Article
- A biomarker and molecular mechanism investigation for thyroid cancer.Central-European journal of immunology · 2023Article
- Emerging mechanisms progress of colorectal cancer liver metastasis.Frontiers in endocrinology · 2022Review
- Impact of Selected Signaling Proteins on SNAIL 1 and SNAIL 2 Expression in Ovarian Cancer Cell Lines in Relation to Cells' Cisplatin Resistance and EMT Markers Level.International journal of molecular sciences · 2021Article
- Genomics and prognosis analysis of epithelial-mesenchymal transition in colorectal cancer patients.BMC cancer · 2020Article
- Review
- Ponicidin inhibits pro-inflammatory cytokine TNF-α-induced epithelial-mesenchymal transition and metastasis of colorectal cancer cells via suppressing the AKT/GSK-3β/Snail pathway.Inflammopharmacology · 2019Article
- Regulation of miRNAs by Snail during epithelial-to-mesenchymal transition in HT29 colon cancer cells.Scientific reports · 2019Article
- Smad4 and epithelial-mesenchymal transition proteins in colorectal carcinoma: an immunohistochemical study.Journal of molecular histology · 2018Article
- Upregulation of NETO2 gene in colorectal cancer.BMC genetics · 2017Article
- MiR-675-5p supports hypoxia induced epithelial to mesenchymal transition in colon cancer cells.Oncotarget · 2017Article
- Snail and serpinA1 promote tumor progression and predict prognosis in colorectal cancer.Oncotarget · 2015Article
- Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium.The EMBO journal · 2015Article
- FOXM1 promotes lung adenocarcinoma invasion and metastasis by upregulating SNAIL.International journal of biological sciences · 2015Article
- Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention.Journal of experimental & clinical cancer research : CR · 2014Review
- Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- LIM protein JUB promotes epithelial-mesenchymal transition in colorectal cancer.Cancer science · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overexpression of the transcriptional repressor, SNAIL, has been implicated in the pathogenesis of a number of malignancies; however, there are no previous reports on the role of SNAIL in colorectal cancers (CRCs). We, therefore, evaluated human CRC specimens for the presence of the SNAIL protein. Immunohistochemical studies were performed using samples obtained from archived CRC paraffin blocks and a tissue array. Tissue sections were probed with a polyclonal antibody to human SNAIL and scored by a gastrointestinal pathologist. SNAIL was not detectable in uninvolved mucosa, but immunoreactivity was evident in 78% of tumors. SNAIL protein expression did not correlate with subsite location or gender, however, SNAIL-positive tumors had an older mean age (58.9 +/- 12.7 versus 49.8 +/- 127; P = 0.028). Furthermore, there was a trend that CRCs with metastatic ability more frequently overexpressed SNAIL (100 versus 65%; P = 0.11). In conclusion, we demonstrate, for the first time, that SNAIL is upregulated in human colon cancer, which potentially may have significance in control of metastasis and possibly serve as a target for chemopreventive agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.