ArticleHuman genetics2005
Non-recombining chromosome Y haplogroups and centromeric HindIII RFLP in relation to blood pressure in 2,743 middle-aged Caucasian men from the UK.
Article in Human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Limited Effect of Y Chromosome Variation on Coronary Artery Disease and Mortality in UK Biobank-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- Review
- The Challenges of Chromosome Y Analysis and the Implications for Chronic Kidney Disease.Frontiers in genetics · 2019Review
- Associations of Y chromosomal haplogroups with cardiometabolic risk factors and subclinical vascular measures in males during childhood and adolescence.Atherosclerosis · 2018Article
- Using Y-Chromosomal Haplogroups in Genetic Association Studies and Suggested Implications.Genes · 2018Article
- The Y chromosome: a blueprint for men's health?European journal of human genetics : EJHG · 2017Review
- Chromosome Y genetic variants: impact in animal models and on human disease.Physiological genomics · 2015Review
- Genetic polymorphism of human Y chromosome and risk factors for cardiovascular diseases: a study in WOBASZ cohort.PloS one · 2013Article
- Selected Abstracts from the XXII National Congress of the Italian Society of Hypertension: 2005 September 27-30, Turin, Italy.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2005Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence from rodents and association analyses in humans suggest the presence on chromosome Y of one or more genes affecting blood pressure (BP). The HindIII centromeric alphoid polymorphism has been reported to be associated with BP in three independent human populations, although other studies reported null associations with this trait. Our objective was to test for association between BP and genetic variation of the Y chromosome. To this end, 2,743 unrelated Caucasian men recruited from nine UK practices were analysed for five SNPs (including the HindIII site) and two microsatellites spanning the non-recombining region of the Y chromosome. Systolic and diastolic BP were analysed both as quantitative traits and as categorical variables. Differences between locations were tested. Haplotypic and linkage disequilibrium (LD) analyses were also performed. Overall, no significant association was found between any of the loci analysed and BP, although post hoc analyses suggest a possible relation of specific Y haplogroups to BP. The HindIII polymorphism marks major structural differences in the Y centromere which could influence mitotic loss during ageing, or other somatic events. However, this study does not support a causal effect on BP, although association of one or more Y haplogroups cannot be excluded.
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