Evidence map›Paper›PMID 15711820›Full record

Trial reportLangenbeck's archives of surgery2005

Synbiotics reduce postoperative infectious complications: a randomized controlled trial in biliary cancer patients undergoing hepatectomy.

Hidetoshi Kanazawa, Masato Nagino, Satoshi Kamiya, Shunichiro Komatsu, Toshihiko Mayumi, Kenji Takagi, Takashi Asahara, Koji Nomoto, Ryuichiro Tanaka, Yuji Nimura

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Langenbeck's archives of surgery, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01683708 (Effectiveness of Perioperative Symbiotic Therapy to Reduce Infectious Morbidity in Jaundiced Patients), which is not on this map. Cited by 77 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 18 pooled it
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01683708 unknown statusnot on this mapstarted 2008, after this paper: background citation

Effectiveness of Perioperative Symbiotic Therapy to Reduce Infectious Morbidity in Jaundiced Patients: a Randomized Controlled Trial

TypeobservationalSponsorAzienda Ospedaliera Ordine Mauriziano di TorinoRan2008Enrolled20ConditionsPostoperative Infections, JaundiceArmsSymbiotic therapy
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 18 syntheses or guidelines pooled it, 252 citations in OpenAlex.

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  13. Probiotics and Synbiotics Decrease Postoperative Sepsis in Elective Gastrointestinal Surgical Patients: a Meta-Analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016
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  15. Methods of decreasing infection to improve outcomes after liver resections.The Cochrane database of systematic reviews · 2011
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hidetoshi KanazawaDivision of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
Masato Nagino
Satoshi Kamiya
Shunichiro Komatsu
Toshihiko Mayumi
Kenji Takagi
Takashi Asahara
Koji Nomoto
Ryuichiro Tanaka
Yuji Nimura
Nagoya University · JPYakult Central Institute · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsThe clinical value of synbiotics in surgical patients remains unclear. The aim of this study was to investigate the effect of synbiotics on intestinal integrity and microflora, as well as on surgical outcome, in patients undergoing high-risk hepatectomy.

methodsFifty-four patients with biliary cancer were randomly allocated to two groups before hepatectomy. One group received postoperative enteral feeding that included synbiotics; the other received enteral feeding only. Lactulose/mannitol (L/M) ratio, serum diamine oxidase (DAO) activity, and fecal microflora and organic acid concentrations were determined. Postoperative infectious complications were recorded.

resultsOf the 54 patients, 44 completed the trial (21 receiving synbiotics and 23 others as controls). Postoperative changes in L/M ratios and serum DAO activities were identical between the two groups. Numbers of beneficial bacteria increased in the synbiotics group after surgery but decreased in controls. Numbers of harmful microorganisms decreased in the synbiotics group but increased in controls. Total organic acid concentrations increased in the synbiotics group but decreased in controls. Incidence of infectious complications was 19% (4/21) in the synbiotics group and 52% (12/23) in controls (P<0.05). All study patients tolerated surgery (mortality 0%).

conclusionsSynbiotics, combined with early enteral nutrition, can reduce postoperative infections. This beneficial effect presumably involves correction of an intestinal microbial imbalance induced by surgical stress.

Indexed as

BifidobacteriumBile Ducts, IntrahepaticEnteral NutritionHepatectomyLacticaseibacillus caseiAgedBiliary Tract NeoplasmsCholangiocarcinomaFemaleHumansIntestinal MucosaIntestinesMaleMiddle AgedProspective StudiesTreatment Outcome

Identifiers

PMID15711820
OpenAlexW1982742398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.