ArticleProceedings of the National Academy of Sciences of the United States of America2005
Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis.Public health nutrition · 2015Pooled it
- Blood metabolic biomarkers and colorectal cancer risk: results from large prospective cohort and Mendelian randomisation analyses.British journal of cancer · 2025Article
- Theracurmin inhibits intestinal polyp development in Apc-mutant mice by inhibiting inflammation-related factors.Cancer science · 2020Article
- The Radical Scavenger NZ-419 Suppresses Intestinal Polyp Development inJournal of clinical medicine · 2020Article
- Chemopreventive effects of a low-side-effect antibiotic drug, erythromycin, on mouse intestinal tumors.Journal of clinical biochemistry and nutrition · 2017Article
- Preventive Effects of Heat-Killed Enterococcus faecalis Strain EC-12 on Mouse Intestinal Tumor Development.International journal of molecular sciences · 2017Article
- Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells and modifies intestinal polyp development in Apc (Min/+) mice.Journal of clinical biochemistry and nutrition · 2014Article
- Chemopreventive effects of RXR-selective rexinoid bexarotene on intestinal neoplasia of Apc(Min/+) mice.Neoplasia (New York, N.Y.) · 2012Article
- Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum alleviates age-inflicted oxidative stress and improves expression of biomarkers of ageing in mice.Molecular biology reports · 2012Article
- Lipoprotein lipase as a candidate target for cancer prevention/therapy.Biochemistry research international · 2012Article
- Lipid-regulating effect of traditional chinese medicine: mechanisms of actions.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma.Melanoma research · 2011Article
- C57BL/KsJ-db/db-Apc mice exhibit an increased incidence of intestinal neoplasms.International journal of molecular sciences · 2011Article
- Genetic and epigenetic inactivation of LPL gene in human prostate cancer.International journal of cancer · 2009Article
- Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colon.PLoS genetics · 2009Article
- Relationships between intestinal polyp formation and fatty acid levels in plasma, erythrocytes, and intestinal polyps in Min mice.Cancer science · 2008Article
- Susceptibility of Snark-deficient mice to azoxymethane-induced colorectal tumorigenesis and the formation of aberrant crypt foci.Cancer science · 2008Article
- PPARalpha Ligands as Antitumorigenic and Antiangiogenic Agents.PPAR research · 2008Article
- Phenotypic reversion in analbuminemic rats due to an altered splicing mechanism.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2007Review
- Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea.Cancer science · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously reported a hyperlipidemic state in two strains of Apc-deficient mice, Min and Apc(1309), associated with low expression levels of lipoprotein lipase (LPL) in the liver and small intestine, and enforced induction of LPL mRNA by peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma agonists clearly suppressed hyperlipidemia and intestinal polyp formation in these mice. Meanwhile, a compound, NO-1886, has been shown to increase LPL mRNA and protein levels but not to possess PPARalpha and PPARgamma agonistic activity. In this study, therefore, the effects of NO-1886 on hyperlipidemia and intestinal polyp formation were investigated in Min mice. Administration of 400 and 800 ppm NO-1886 in the diet for 13 weeks from 7 weeks of age caused a reduction of serum triglycerides to 39% and 31% of the untreated value, respectively, and the values for very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were improved almost to the wild-type level with a corresponding elevation of the LPL mRNA. Moreover, total numbers of intestinal polyps in the groups receiving NO-1886 at 400 and 800 ppm were decreased to 48% and 42% of the control value, respectively. We also found that NO-1886 suppressed cyclooxygenase-2 transcriptional promoter activity in a reporter gene assay and reduced cyclooxygenase-2 mRNA levels in the small intestine of Min mice. These results indicate that suppression of serum lipid levels by increasing LPL activity may contribute to a reduction of intestinal polyp formation with Apc-deficiency, and NO-1886 and its derivatives could be useful as chemopreventive agents for colon cancer.
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