ArticleProceedings of the National Academy of Sciences of the United States of America2005
Embryonic pig liver, pancreas, and lung as a source for transplantation: optimal organogenesis without teratoma depends on distinct time windows.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 57 citations in OpenAlex.
- Association between Head-to-Chest Circumference Ratio and Intrauterine Growth-Retardation Related Outcomes during Preweaning and Postweaning.Animals : an open access journal from MDPI · 2022Article
- Skeletal Muscle Stem Cells from PSC-Derived Teratomas Have Functional Regenerative Capacity.Cell stem cell · 2018Article
- Preconditioning allows engraftment of mouse and human embryonic lung cells, enabling lung repair in mice.Nature medicine · 2015Article
- Engineering liver tissue from induced pluripotent stem cells: a first step in generating new organs for transplantation?Hepatology (Baltimore, Md.) · 2013Article
- Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease.EMBO molecular medicine · 2013Article
- Fetal pancreas as a source for islet transplantation: sweet promise and current challenges.Diabetes · 2013Article
- Engraftment of insulin-producing cells from porcine islets in non-immune-suppressed rats or nonhuman primates transplanted previously with embryonic pig pancreas.Journal of transplantation · 2011Article
- Xenotransplantation of embryonic pig kidney or pancreas to replace the function of mature organs.Journal of transplantation · 2011Article
- Therapeutic window, a critical developmental stage for stem cell therapies.Current stem cell research & therapy · 2010Review
- Engraftment of cells from porcine islets of Langerhans and normalization of glucose tolerance following transplantation of pig pancreatic primordia in nonimmune-suppressed diabetic rats.The American journal of pathology · 2010Article
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- Enhancement of pig embryonic implants in factor VIII KO mice: a novel role for the coagulation cascade in organ size control.PloS one · 2009Article
- Article
- Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Subcutaneous transplantation of embryonic pancreas for correction of type 1 diabetes.American journal of physiology. Endocrinology and metabolism · 2009Article
- Hepatic reconstruction from fetal porcine liver cells using a radial flow bioreactor.World journal of gastroenterology · 2008Article
- Normalization of glucose post-transplantation into diabetic rats of pig pancreatic primordia preserved in vitro.Organogenesis · 2008Article
- Organogenesis of kidney and endocrine pancreas: the window opens.Organogenesis · 2007Article
- Growing organs for transplantation from embryonic precursor tissues.Immunologic research · 2007Article
- Correction of hemophilia as a proof of concept for treatment of monogenic diseases by fetal spleen transplantation.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pig embryonic tissues represent an attractive option for organ transplantation. However, the achievement of optimal organogenesis after transplantation, namely, maximal organ growth and function without teratoma development, represents a major challenge. In this study, we determined distinct gestational time windows for the growth of pig embryonic liver, pancreas, and lung precursors. Transplantation of embryonic-tissue precursors at various gestational ages [from E (embryonic day) 21 to E100] revealed a unique pattern of growth and differentiation for each embryonic organ. Maximal liver growth and function were achieved at the earliest teratoma-free gestational age (E28), whereas the growth and functional potential of the pancreas gradually increased toward E42 and E56 followed by a marked decline in insulin-secreting capacity at E80 and E100. Development of mature lung tissue containing essential respiratory system elements was observed at a relatively late gestational age (E56). These findings, showing distinct, optimal gestational time windows for transplantation of embryonic pig liver, pancreas, and lung, might explain, in part, the disappointing results in previous transplantation trials and could help enhance the chances for successful implementation of embryonic pig tissue in the treatment of a wide spectrum of human diseases.
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