ArticlePlant physiology2005
Comparative genomics of two closely related unicellular thermo-acidophilic red algae, Galdieria sulphuraria and Cyanidioschyzon merolae, reveals the molecular basis of the metabolic flexibility of Galdieria sulphuraria and significant differences in carbohydrate metabolism of both algae.
Article in Plant physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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61 citing papers in PubMed, 207 citations in OpenAlex.
- Comparative Analysis of Carbohydrate-Active Enzyme (CAZyme) Diversity Across Diverse Algal Lineages.Marine biotechnology (New York, N.Y.) · 2026Article
- Sexual life cycle establishes the unicellular red algae Cyanidiophyceae as a genetically tractable model for eukaryotic evolution.The Plant cell · 2026Article
- Target of Rapamycin Coordinates Metabolic Remodeling at the Protein Level in the Red AlgaPlants (Basel, Switzerland) · 2026Article
- IPTG- and estradiol-inducible gene expression systems in the unicellular red alga Cyanidioschyzon merolae.Plant physiology · 2026Article
- Costs of photosynthesis and cellular remodeling in trophic transitions of the unicellular red alga Galdieria partita.Communications biology · 2025Article
- Target of rapamycin signaling regulates starch degradation via α-glucan water dikinase in a unicellular red alga.Plant physiology · 2025Article
- Biological and Nutritional Applications of Microalgae.Nutrients · 2024Review
- Feasibility study on heterotrophic utilization of galactose by Chlorella sorokiniana and promotion of galactose utilization through mixed carbon sources culture.Biotechnology for biofuels and bioproducts · 2024Article
- Jasmonates and Ethylene Shape Floridoside Synthesis during Carposporogenesis in the Red SeaweedMarine drugs · 2024Article
- Contribution to a Sustainable Society: Biosorption of Precious Metals Using the MicroalgaInternational journal of molecular sciences · 2024Article
- Valuable pigments from microalgae: phycobiliproteins, primary carotenoids, and fucoxanthin.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Review
- The carbon-concentrating mechanism of the extremophilic red microalga Cyanidioschyzon merolae.Photosynthesis research · 2023Article
- Natural carbon fixation and advances in synthetic engineering for redesigning and creating new fixation pathways.Journal of advanced research · 2023Review
- Life cycle and functional genomics of the unicellular red algaProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Physiological and multi-omics responses of Neoporphyra haitanensis to dehydration-rehydration cycles.BMC plant biology · 2022Article
- Cell size for commitment to cell division and number of successive cell divisions in cyanidialean red algae.Protoplasma · 2021Article
- Mixotrophic growth of the extremophile Galdieria sulphuraria reveals the flexibility of its carbon assimilation metabolism.The New phytologist · 2021Article
- The Unicellular Red AlgaPlants (Basel, Switzerland) · 2021Review
- Grand Challenges in Microalgae Domestication.Frontiers in plant science · 2021Article
- Putative trehalose biosynthesis proteins function as differential floridoside-6-phosphate synthases to participate in the abiotic stress response in the red alga Pyropia haitanensis.BMC plant biology · 2019Article
1 more citing papers are in PubMed but not listed here.
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8 authors at 2 institutions in 2 countries.
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Abstract
Unicellular algae serve as models for the study and discovery of metabolic pathways, for the functional dissection of cell biological processes such as organellar division and cell motility, and for the identification of novel genes and gene functions. The recent completion of several algal genome sequences and expressed sequence tag collections and the establishment of nuclear and organellar transformation methods has opened the way for functional genomics approaches using algal model systems. The thermo-acidophilic unicellular red alga Galdieria sulphuraria represents a particularly interesting species for a genomics approach owing to its extraordinary metabolic versatility such as heterotrophic and mixotrophic growth on more than 50 different carbon sources and its adaptation to hot acidic environments. However, the ab initio prediction of genes required for unknown metabolic pathways from genome sequences is not trivial. A compelling strategy for gene identification is the comparison of similarly sized genomes of related organisms with different physiologies. Using this approach, candidate genes were identified that are critical to the metabolic versatility of Galdieria. Expressed sequence tags and high-throughput genomic sequence reads covering >70% of the G. sulphuraria genome were compared to the genome of the unicellular, obligate photoautotrophic red alga Cyanidioschyzon merolae. More than 30% of the Galdieria sequences did not relate to any of the Cyanidioschyzon genes. A closer inspection of these sequences revealed a large number of membrane transporters and enzymes of carbohydrate metabolism that are unique to Galdieria. Based on these data, it is proposed that genes involved in the uptake of reduced carbon compounds and enzymes involved in their metabolism are crucial to the metabolic flexibility of G. sulphuraria.
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