Evidence map›Paper›PMID 15709044›Full record

ArticleJournal of virology2005

Chimeric human immunodeficiency virus type 1 virions that contain the simian immunodeficiency virus nef gene are cyclosporin A resistant.

Mahfuz Khan, Lingling Jin, Lesa Miles, Vincent C Bond, Michael D Powell

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mahfuz KhanDept. of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, 720 Westview Dr. SW, Atlanta, GA 30310, USA. powellm@msm.edu
Lingling Jin
Lesa Miles
Vincent C Bond
Michael D Powell
Morehouse School of Medicine · US

Funding

TRANSCRIPTION FACTORS AND PROSTATE CANCERG12RR003034 · NCRR · MOREHOUSE SCHOOL OF MEDICINE · PI ZHAO, XUEYING · 1986 to 2011
$32.4M
Vascular Cell Apoptosis: Mediator Role of Transforming Growth Factor-beta-1S06GM008248 · NIGMS · MOREHOUSE SCHOOL OF MEDICINE · PI SILVA, ANISIA J · 1989 to 2009
$19.8M
The Role of Nef and Cyclophilin A in HIV-1 DisassemblyR21AI060370 · NIAID · MOREHOUSE SCHOOL OF MEDICINE · PI POWELL, MICHAEL D · 2004 to 2005
$351k
NCRR NIH HHS G12 RR003034NCRR NIH HHS G12-RR03034NIAID NIH HHS R21 AI060370NIAID NIH HHS R21AI60370NIGMS NIH HHS S06 GM008248NIGMS NIH HHS S06GM08248
6 · The paper itself

Abstract

We have previously shown that human immunodeficiency virus type 1 (HIV-1) virions which have their own nef gene deleted and are trans complemented to contain HIV-2 or simian immunodeficiency virus (SIV) Nef become resistant to treatment with cyclosporin A. To expand and confirm these studies, we have tested an HIV-1 isolate in which the HIV-1 nef gene has been replaced by the nef gene from SIV in a multiround infectivity assay using more physiologically relevant cell types. Our results confirm that HIV-1 virions that contain SIV nef can replicate in a cyclophilin-independent fashion.

Indexed as

Genes, nefAnimalsCell LineChimeraCyclosporineDrug Resistance, ViralGenetic Complementation TestHIV-1HumansIn Vitro TechniquesLeukocytes, MononuclearSimian Immunodeficiency VirusVirus ReplicationCyclosporine

Identifiers

PMID15709044
PMCPMC548445
OpenAlexW2106269162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.